Saururus chinensis Prevents Estrogen Deficiency-Induced Osteoporosis in Rats: A Metabolomic Study Using UPLC/Q-TOF MS

Lee, Sang‐Hee; Jang, Gwang Ju; Yoo, Miyoung; Hur, Haeng Jeon; Sung, Mi Jeong

doi:10.3390/app11041392

Cited by 1 publication

(2 citation statements)

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“…More and more studies have verified that several lactic acid bacteria are capable of the biohydrogenation of linoleic acid ( 73 ). Recent study also revealed the prevention of PMOP in OVX rats by Saururus chinensis extract due to the involvement of linoleic acid ( 22 ). In our study, the GM significantly correlated to metabolites were belonging to two independent families Aerococcacease ( Globicatella ) and Lactobacillaceae ( Lactobacillus ) in the same order Lactobacillales of Firmicutes ( Figures 8 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

“…The significant correlations between GM and serum RANK, OPG and TRACP or inflammatory factors suggested a potential role of GM-bone axis in improving PMOP ( 21 ). More and more studies have also shown an influence of the altered GM on gut homeostasis via regulating bile acid, amino acid and fatty acid metabolisms, thereby leading to an improvement of PMOP ( 22 – 24 ). Correspondingly, those GM capable of bile acid, amino acid and fatty acid metabolisms were already used to prevent PMOP in OVX model ( 18 , 24 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model

Wang

et al. 2022

Front. Endocrinol.

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Postmenopausal osteoporosis (PMOP) is an estrogen deficiency-induced bone loss, which has been shown an association with an altered gut microbiota (GM). Gut microbiota-bone axis has been recognized as a crucial mediator for bone homeostasis. Icariin (ICA) is an effective agent to delay bone loss by regulating the bone homeostasis. Thus, we hypothesize that ICA can prevent bone loss by modulating GM and regulating metabolite alterations. The effects of ICA on bone metabolism improvement in ovariectomized (OVX) rats and their relationships with the GM and fecal metabolites were investigated. Micro-computed tomography (micro-CT) and hematoxylin-eosin (HE) staining showed a typical bone boss in OVX group, while ICA or estradiol (E2) administration exhibited positive effects on bone micro-architecture improvement. The GM such as Actinobacteria, Gammaproteobacteria, Erysipelotrichi, Erysipelotrichales, Enterobacteriales, Actinomycetales, Ruminococcus and Oscillospira significantly correlated to serum bone Gla-protein (BGP), receptor activator of nuclear factor-κB (RANK), receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG) and tartrate resistant acid phosphatase (TRACP). Further t-test revealed a substantial variation of the GM and fecal metabolites in different treatments. Among them, Lachnoclostridium, Butyricimonas, Rikenella, Paraprevolla, Adlercreutzia, Enterorhabdus, Anaerovorax, Allobaculum, Elusimicrobium, Lactococcus, Globicatella and Lactobacillus were probably the key microbial communities driving the change of bile acid, amino acid and fatty acid, thereby leading to an improvement of PMOP. The significant up-regulation of L-Saccharopine, 1-Aminocyclohexadieneacid and linoleic acid after ICA administration suggested important contributions of amino acid and fatty acid metabolisms in the prevention and treatment of PMOP. Taken together, our study has provided new perspectives to better understand the effects of ICA on PMOP improvement by regulating GM and the associated fecal metabolites. Our findings contribute to develop ICA as a potential therapy for PMOP.

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Section: Discussionmentioning

confidence: 99%