Sauropus Androgynus for Increasing Uterine Weight in Menopausal Women: An Experimental Study Using Animal Models

Abstract

Menopause is a natural phase of life and happens in every woman who reaches a certain age. This condition has many problems, such as endometrial atrophy, which can cause abnormal bleeding. Sauropus androgynus, known as Katu Leaf, has isoflavones compound and acts as an estrogen-like agent or phytoestrogen. Isoflavone can induce cell proliferation activity in increasing endometrial thickness and uterine weight. This study was aimed to find how the is flavone compound in Sauropus androgynus can increase the uterine weight in menopausal mice as an animal model. Twenty female mice aged two months and one week were given VCD (4-Vinyl cyclohexane dioxide) to induce the atresia acceleration of ovarian follicles, then treated with Katu Leaf extract of 0, 15 and 30mg/kgBW over four weeks. The uterine weights were measured and analyzed with One Way Analysis of Variances (Anova) and further tested with Least Significance Difference in 95% confidence interval. The result showed a difference between control and treatments group (p<0.05) with 30mg/kgBW as highest dosage, which increase uterine weight as 112.80 +8.86mg), but this is not higher than normal (116.36+6.83mg). This study suggests that Katu Leaf extract has an isoflavone compound which can increase uterine weight in menopausal mice.

Physiological responses of Catfish liver to katuk extract, turmeric powder, and vitamin C supplemented in the diet during ovarium development

“…Katuk leaves (Sauropus androgynus) contain secondary metabolite compounds such as sterol compounds, tannins, saponins, terpenoids, phenols, and (Awaludin et al 2020) Potential estrogenic effects on S. androgenus have an impact on the reproductive process, and katuk extract has direct and indirect effects on the reproductive system, which is related to estrogen receptors; apart from that, it also contains iso avone compounds and acts as an agent similar to estrogen and phytoestrogen which shows potential estrogenic properties (Hikmah & Susilowati, 2017;Susilowati et al, 2020). Each treatment group with the addition of katuk extract showed high HSI values, which proves that the estrogen compounds contained in katuk extract stimulate growth and development of the livers of cat sh.…”

Total Flavonoid dan Aktivitas Antioksidan Food Bar Torbangun – Katuk terhadap Efektivitas Produksi ASI

“…Some phytoestrogens are diosgenin, anethole estragole, shatavarine silybin, kaempferol, quercetin, silydianin, silychristin 7 . Damanik et al (2017) found that in Torbangun leaves, there are digiprolactone and kaempferol derivatives (flavonoids of the flavonol group) 22,23 , while Katuk leaves contain isoflavones and quercetin as phytoestrogens 24 . The galactagogue mechanism of phytoestrogens occurs in anterior pituitary lactotrophic cells and the mammary glands.…”