Sauerstoffdruck und Durchblutung im gesunden und koronarinsuffizienten Myokard des Hundes und ihre Beeinflussung durch koronarerweiternde Pharmaka

Kadatz, R

doi:10.1007/bf02119665

Cited by 16 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most previous studies have been concerned with the effects of dipyridamole on blood flow in an area of myocardium made chronically ischaemic by the gradual occlusion of a major coronary artery (Fam & McGregor, 1965;Kadatz, 1969). The present studies are concerned with the effects of the drug on blood flow and oxygen handling after 2-3 h of ischaemia and are relevant to the problem of whether it is possible, by pharmacological means, to improve oxygen availability to an ischaemic area within the first few hours of an infarction.…”

Section: Discussionmentioning

confidence: 99%

“…Using a heat clearance technique a number of authors (Kiese, Lange & Resag, 1960;Lange, 1964;Kadatz, 1969;Grayson et al, 1971) have demonstrated that dipyridamole increases flow in experimental infarcts in dogs. This flow change is rather less than that which occurs in normal cardiac muscle.…”

Section: Introductionmentioning

confidence: 99%

“…Of the increasing number of coronary vasodilator drugs available most experimental work has been done with dipyridamole (for references and a recent summary of activity see Parratt, 1969). Using a heat clearance technique a number of authors (Kiese, Lange & Resag, 1960;Lange, 1964;Kadatz, 1969;Grayson et al, 1971) have demonstrated that dipyridamole increases flow in experimental infarcts in dogs. This flow change is rather less than that which occurs in normal cardiac muscle.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effects of dipyridamole on blood flow and oxygen handling in the acutely ischaemic and normal canine myocardium

Marshall

Parratt

1973

British J Pharmacology

View full text Add to dashboard Cite

Summary1. The effects of the intravenous administration of dipyridamole (0 25 mg/kg) were examined in a canine preparation that enabled simultaneous measurements to be made of blood flow in ischaemic and in essentially normal areas of the myocardium and also of oxygen handling (availability, consumption and extraction) in both these regions. 2. When administered to dogs anaesthetized with trichlorethylene 2-3 h after acute ligation of the descending branch of the left coronary artery, dipyridamole markedly increased blood flow in essentially normal regions (left circumflex flow) but failed to increase flow in the area supplied by the ligated vessel (measured by "xenon clearance and by retrograde flow). In five of the six animals definite decreases in flow ('stealing') were observed in the ischaemic region. These flow changes were related to the decreased trans-ventricular perfusion pressure (diastolic peripheral coronary pressure minus left ventricular end-diastolic pressure) and were accompanied by electrocardiographic evidence of increasingly severe myocardial ischaemia. The results support the suggestion that only increasing the perfusion gradient will usefully improve blood flow (and hence oxygen availability) to the acutely ischaemic myocardium. 3. Despite these effects on ischaemic muscle blood flow, the oxygen tension of the blood draining the infarcting muscle was markedly elevated. The conclusion is drawn that dipyridamole decreases the efficiency of the myocardial circulation by opening up vessels that do not take part in tissue exchange.

show abstract

Section: Discussionmentioning

confidence: 99%