Saudi anti-human cancer plants database (SACPD): A collection of plants with anti-human cancer activities

Abstract

Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD). The database contains most of the reported information about the naturally growing Saudi anticancer plants. SACPD comprises the scientific and local names of 91 plant species that grow naturally in Saudi Arabia. These species belong to 38 different taxonomic families. In Addition, 18 species that represent16 family of medicinal plants and are intensively sold in the local markets in Saudi Arabia were added to the database. The website provides interesting details, including plant part containing the anticancer bioactive compounds, plants locations and cancer/cell type against which they exhibit their anticancer activity. Our survey revealed that breast, liver and leukemia were the most studied cancer cell lines in Saudi Arabia with percentages of 27%, 19% and 15%, respectively. The current SACPD represents a nucleus around which more development efforts can expand to accommodate all future submissions about new Saudi plant species with anticancer activities. SACPD will provide an excellent starting point for researchers and pharmaceutical companies who are interested in developing new anticancer drugs. SACPD is available online at https://teeqrani1.wixsite.com/sapd

Chemical characterization, antidiabetic and anticancer activities of Santolina chamaecyparissus

“…The anticancer activity of S. chamaecyparissus growing in Saudi Arabia was investigated by El-sharkawy (2014) , against A549, HCT116, HepG2, and MCF-7 cell lines; the study results showed that the S. chamaecyparissus was effective against HepG2 cell lines. S. chamaecyparissus also reported by other researchers as a potential plant with anticancer activity ( Elsharkawy and Aljohar, 2016 , Al-Zahrani, 2018 ). The current study findings indicated the possible role of S. chamaecyparissus in negative regulation of EGFR protein, which can be helpful in the management of human breast cancer.…”

Saudi Arabian Plants: A Powerful Weapon against a Plethora of Diseases

“…About 91 plant species from SA belonging to 38 families have exhibited anti-cancer activities against different human cancer cell lines. The plant families that have received the most attention due to their anti-cancer impact are Asteraceae (25%), Apocynaceae (10%), Fabaceae (7%), Boraginaceae (3%), and Brassicaceae (3%) [95]. For example, Catharanthus roseus L., which belongs to the Apocynaceae family, grows throughout in the Kingdom of SA, especially in the Makkah region, and it is known to contain more than 150 valuable alkaloids [96].…”

Assessment of the Anticancer Effect of Chlorojanerin Isolated from Centaurothamnus maximus on A549 Lung Cancer Cells

“…In the field of cancer research, plants are still a potential source for a novel chemical compound [ 2 , 3 ]. With a different biogeographic region, Saudi Arabia provides a remarkably rich source for medicinal plants that have anticancer properties [ 4 , 5 ].…”