Saturation biopsy improves preoperative Gleason scoring of prostate cancer

Kahl, Philip; Wolf, Susanne; Adam, Alexander; Heukamp, Lukas C.; Ellinger, Jörg; Vorreuther, R.; Solleder, Gerold; Buettner, Reinhard

doi:10.1016/j.prp.2008.10.010

Cited by 11 publications

(8 citation statements)

References 21 publications

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“…[26] The results of biopsy schemes involving saturation biopsies (more than 12 cores) appear to have a higher concordance rate with results from prostatectomy (59%) than a scheme involving fewer than 12 cores (47%, p=0.05). [28] The role of lateral sampling of the prostate was evaluated by Singh et al who showed that laterally directed cores were independent predictors of pathological features at prostatectomy. [29]…”

Section: Optimal Prostate Biopsymentioning

confidence: 99%

Standards for prostate biopsy

Bjurlin

Taneja

2014

Current Opinion in Urology

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Purpose of review A variety techniques have emerged for optimization of prostate biopsy. In this review, we summarize and critically discuss the most recent developments regarding the optimal systematic biopsy and sampling labeling along with multiparametric MRI and MR targeted biopsies. Recent findings The use of 10–12-core extended-sampling protocols increases cancer detection rates compared to traditional sextant sampling and reduces the likelihood that patients will require a repeat biopsy, ultimately allowing more accurate risk stratification without increasing the likelihood of detecting insignificant cancers. As the number of cores increases above 12 cores, the increase in diagnostic yield becomes marginal. However, limitations of this technique include undersampling, over-sampling, and the need for repetitive biopsy. MRI and MR-targeted biopsies have demonstrated superiority over systematic biopsies for the detection of clinically significant disease and representation of disease burden, while deploying fewer cores and may have applications in men undergoing initial or repeat biopsy and those with low risk cancer on or considering active surveillance. Summary A 12-core systematic biopsy that incorporates apical and far-lateral cores in the template distribution allows maximal cancer detection, avoidance of a repeat biopsy, while minimizing the detection of insignificant prostate cancers. MRI guided prostate biopsy has an evolving role in both initial and repeat prostate biopsy strategies, as well as active surveillance, potentially improving sampling efficiency, increasing detection of clinically significant cancers, and reducing detection of insignificant cancers.

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Section: Optimal Prostate Biopsymentioning

confidence: 99%

Standards for prostate biopsy

Bjurlin

Taneja

2014

Current Opinion in Urology

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“…21 The results of biopsy schemes involving saturation biopsies (more than 12 cores) appear to have a higher concordance rate with results from prostatectomy (59%) than a scheme involving fewer than 12 cores (47%, p=0.05). 22 …”

Section: Optimizing Prostate Biopsy In Clinical Practice – Core Numentioning

confidence: 99%

Optimization of Prostate Biopsy

Bjurlin

Wysock

Taneja

2014

Urologic Clinics of North America

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“…Three studies showed benefits to grading prediction from increasing the number of cores (Table 2). Saturation biopsy with a mean of 24 cores proved superior to conventional biopsy with a mean of nine cores for preoperative Gleason score prediction [40]. Other studies compared a mean of 12 cores [41] or 11 cores [42] (an extended biopsy but not a saturation biopsy by current standards) to 6 cores.…”

Section: Second-opinion Concordance In Gleason Gradingmentioning

confidence: 99%

Current Perspectives on Gleason Grading of Prostate Cancer

Iczkowski

Lucia

2011

Curr Urol Rep

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The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordance in Gleason grading; the persistence of grading discrepancies with frequent upgrading from the biopsy to the prostatectomy specimen; the 2005 International Society of Urologic Pathologists' modifications to Gleason grading; the impact of this modified grading on grade migration and outcome prediction; and molecular correlates of cancer morphology. Data from the most recent years are emphasized.

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Saturation biopsy improves preoperative Gleason scoring of prostate cancer

Cited by 11 publications

References 21 publications

Standards for prostate biopsy

Standards for prostate biopsy

Optimization of Prostate Biopsy

Current Perspectives on Gleason Grading of Prostate Cancer

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