Satoyoshi Syndrome

Oyama, M.

doi:10.1001/archderm.135.1.91

Cited by 14 publications

(27 citation statements)

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“…Although the etiology remains unidentified, most authors believe that Satoyoshi syndrome may have an autoimmune basis. Laboratory findings often show presence of circulating antinuclear antibodies in many cases . Hypergammaglobulinemia was described in one patient .…”

Section: Pathogenesismentioning

confidence: 95%

“…Growth retardation was observed in 27% of ANA‐positive versus 86% of ANA‐negative, what can be attributed to the lower age of disease onset in ANA‐negative patients. In all ANA‐positive patients, a decrease in number and frequency of muscle spasms, improvement in diarrhea and partial (temporary) or full hair regrowth was observed after introduction of systemic glucocorticosteroid therapy …”

Section: Coexisting Diseasesmentioning

confidence: 99%

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Alopecia areata. How not to miss Satoyoshi syndrome?

Rudnicka

Kwiatkowska

Rakowska

et al. 2014

The Journal of Dermatology

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Satoyoshi syndrome is a multisystem disorder of suspected autoimmune etiology, characterized predominantly by alopecia, muscle spasms and diarrhea. Antinuclear antibodies are present in 60% of patients. The syndrome primarily affects girls and young women. Trichoscopy shows regularly distributed yellow dots, indistinguishable from typical alopecia areata. The condition may be easily misdiagnosed and treated as alopecia areata. On the basis of an in-depth analysis of all published cases we developed diagnostic criteria for Satoyoshi syndrome. We also suggest that two subtypes of the disorder should be distinguished, the ANA-positive Satoyoshi syndrome with generally good response to systemic glucocorticosteroid therapy and the ANA-negative Satoyoshi with less favorable prognosis. In our opinion all patients will alopecia areata (in particular alopecia totalis) should be inquired about muscle spasms and diarrhea and tested for antinuclear antibodies to decrease the risk of missing Satoyoshi syndrome.

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Section: Pathogenesismentioning

confidence: 95%

Section: Coexisting Diseasesmentioning

confidence: 99%

Alopecia areata. How not to miss Satoyoshi syndrome?

Rudnicka

Kwiatkowska

Rakowska

et al. 2014

The Journal of Dermatology

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“…Skin biopsies were performed in two previously reported patients with childhood-onset Satoyoshi syndrome (9, 11). The histological findings of the skin were normal in one patient (9), while the other patient exhibited lymphocyte infiltration in the peribulbar area of the deep dermis (11). In contrast, the lymphocyte infiltration had spread to the papillary layer from the reticular layer in the dermis of the pigmented skin in our patient.…”

Section: Discussionmentioning

confidence: 54%

“…Other clinical findings include low levels of serum protein and total cholesterol (2), and endocrine disturbances, such as amenorrhea with a tendency toward the development of a hypoplastic uterus and ovaries (1). Complications of autoimmune diseases, such as myasthenia gravis (5) as well as the presence of autoantibodies (auto-Abs) (2,(6)(7)(8)(9)(10)(11) and responsiveness to treatment with corticosteroids (9,(11)(12)(13) and intravenous immunoglobulin (IVIG), have been reported in patients with Satoyoshi syndrome (7,14), indicating that an autoimmune mechanism may play a role in the onset of this syndrome, although the precise underlying mechanism remain unknown. The age of onset of Satoyoshi syndrome ranges from 5 to 19 years, with a mean age of 11 years (2, 15); however, adult-onset Satoyoshi syndrome is rare, having so far been reported in only a few patients (2,7,(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Adult-onset Satoyoshi Syndrome with Prominent Laterality of Clinical Features

et al. 2014

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We herein report the case of a patient with adult-onset Satoyoshi syndrome. Alopecia was detected on the patient's head, left leg and abdomen, with pigmentation on the left thigh and abdomen. Painful muscle spasms were also noted in the abdomen and left upper and lower extremities, and a sensory disturbance was present in the left thigh. A skin biopsy of this field showed lymphocyte infiltration, and the patient was found to be positive for antinuclear antibodies and rheumatoid factor. These clinical findings were atypical, as they were lateralized. This case is the first report of Satoyoshi syndrome associated with a sensory disturbance. The patient's histological findings and positivity for autoantibodies indicated the presence of immunological abnormalities in this case of Satoyoshi syndrome.

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“…Se han utilizado para tratarlos, dantrolen, benzodiacepínicos, anticonvulsivantes y toxina botulínica 2,12 con resultados variables y que no están enfocados a la patogenia de la enfermedad. Desde los años noventa la mayoría de los pacientes con síndrome de Satoyoshi se han beneficiado del tratamiento con corticoides que se ha mantenido por más de un año 5,11 , con una significativa reducción de los espasmos musculares, revirtiendo la caída del cabello y logrando el inicio de la menstruación en algunos casos de mujeres afectadas 5,[7][8][9]11,15,[17][18][19][20] . También se han utilizado inmunosupresores como metotrexato, tacrolimus e inmunoglobulinas 9,11 que pueden ser alternativas útiles cuando las dosis de esteroides necesarias para revertir los síntomas ocasionan efectos adversos indeseables o respuesta parcial.…”

Section: Discussionunclassified