Satisfaction with prophylactic risk-reducing salpingo-oophorectomy in BRCA mutation carriers is very high and little dependent on the participants’ characteristics at surgery: a prospective study

Grandi, Giovanni; Sammarini, Margaret; Cortesi, Laura; Toss, Angela; Botticelli, Laura; Varliero, Federico; Sighinolfi, Giovanna; Barbieri, Elena; Facchinetti, Fabio

doi:10.1097/gme.0000000000001737

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…However, separate data from our MFCC have shown a higher rate of actual use of HT after RRSO in women with vasomotor symptoms using our approach to counsel women with BRCA mutations. 35 The data presented here also suggest that a specific information leaflet summarising the major benefits, risks and side effects of the HT in the context of hereditary cancer would be valuable for women at risk and doctors who care for them.…”

Section: Discussionmentioning

confidence: 77%

“…Unfortunately, most women with a BRCA mutation in our study reported that they would not consider taking HT even after risk‐reducing surgery. However, separate data from our MFCC have shown a higher rate of actual use of HT after RRSO in women with vasomotor symptoms using our approach to counsel women with BRCA mutations 35 …”

Section: Discussionmentioning

confidence: 89%

“…However, separate data from our MFCC have shown a higher rate of actual use of HT after RRSO in women with vasomotor symptoms using our approach to counsel women with BRCA mutations. 35 …”

Section: Discussionmentioning

confidence: 99%

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BRCA mutation carriers’ perceptions on postmenopausal hormone therapy: An Italian study

et al. 2021

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Objective: To evaluate the actual perceptions of postmenopausal hormone therapy (HT) in BRCA mutation carriers (BRCAmc) in comparison with women from the general population. Methods: Questionnaire-based study of 83 BRCAmc and a control group of 89 women without a genetic mutation. Perceptions were evaluated by specific questions and Likert scales (−5-+5).Results: Present and past users of HT were more frequent in the control group (p = 0.01), with a longer time of use (p = 0.03). The preferred route of administration of HT was 'oral' (54.6%). The most frequently reported adverse effect of HT was venous thrombosis (0.8), while a protective effect on bone health was reported. No noticeable beneficial effects of HT have been recognised for hot flushes (0.2) and vaginal dryness (0.1). The most frequently perceived beneficial and adverse effects of HT were not significantly different between BRCA mutation carriers and controls. The greatest oncological fear was breast cancer (1.0). The protective role of HT on colorectal cancer was not known (0.1). These oncological impacts were mostly overestimated in BRCAmc, however this was not significant. Few BRCAmc would think of taking HT after risk-reducing surgeries.Conclusions: Knowledge of the effects of HT on BRCAmc is relatively poor and they are likely to overstate its negative effects and underestimate its health benefits; however, this is not significant in comparison to the general population. More and better information should be given to BRCAmc to allow them to make informed decisions about the use of HT, especially before undergoing risk-reducing surgeries.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 89%

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BRCA mutation carriers’ perceptions on postmenopausal hormone therapy: An Italian study

et al. 2021

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Sexual Function in Women Diagnosed with Hereditary Breast and Ovarian Cancer Syndrome

Ferrari,

Amonti,

Giannini

et al. 2024

Cancers

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Background: Hereditary breast and ovarian cancer syndrome (HBOC) predisposes women to an increased risk mainly of breast and tubo-ovarian cancer. The aim of the study is to investigate whether being diagnosed with HBOC syndrome is itself a risk factor for sexual dysfunction. Methods: An ad hoc questionnaire, including baseline demographic and clinical data, and the Sexual Function Questionnaire 28 (SFQ28) were administered to HBOC female carriers (study group) and to a control group. Results: After propensity score matching (1:1), we enrolled 202 women, 101 in the study group and 101 in the control group. In a multivariate analysis, we finally found that menopausal status was the only risk factor for a significant low score in the domains Desire (HR 0.66; CI95% 0.47–0.93; p = 0.017), Arousal (Lubrication) (HR 0.52; CI95% 0.34–0.80; p = 0.003), Arousal (Cognitive) (HR 0.64; CI95% 0.44–0.95; p = 0.027), and Orgasm (HR 0.33; CI95% (0.16–0.70; p = 0.004), independent of risk-reducing surgery for gynecological malignancy. Psycho-oncology support is a protective factor for the Enjoyment domain (HR 1.38; CI95% 1.05–1.81; p = 0.022). Conclusions: HBOC syndrome itself does not affect SFQ28 domains, while menopausal status significantly influences sexual health, with potential mitigating effects of psycho-oncological support.

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Risk-Reducing Salpingo-Oophorectomy (RRSO) Combined with Simultaneous Mastectomy in Women with BRCA 1–2 Mutation Carriers: The Surgical Technique, the Feasibility and Patients’ Satisfaction of Multiple Surgeries

Saccardi

Spagnol

Saibene

et al. 2022

JCM

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The main goal of our study was to evaluate the surgical technique, the feasibility and patient’s satisfaction of multiple surgeries: Risk-reducing salpingo-oophorectomy (RRSO) combined with mastectomy in patients with BRCA 1–2 mutation carriers. We conducted a retrospective analysis of patients with BRCA 1–2 variants who underwent RRSO combined with risk-reducing bilateral mastectomy (RRBM) or surgeries for breast cancer from January-2015 to December-2021. We collected data about surgeries, complications, and patients’ satisfaction using a questionnaire submitted 30 days after surgery. We included 54 patients. Forty-eight patients underwent RRSO, and six patients underwent RRSO + Total laparoscopic hysterectomy (LTH). The minor postoperative complications within 30 days were four: one breast seromas aspiration (1.9%), one infectious reconstructive complication treated with antibiotics therapy (1.9%), one Red-Breast-Syndrome (1.9%) and one trocar abdominal hematoma (1.9%) associated with RRSO. The major postoperative complications within 30 days were five: two evacuations of a breast hematoma (3.7%) and three infectious reconstructive complications treated with removal expander/implant (5.6%). No postoperative complications after 30 days were observed. According to the satisfaction questionnaire, more than 90% of patients were satisfied and would have combined surgery again. In conclusion, the multiple surgeries seem feasible and safety with a single anesthesia, a single surgical time, a single postoperative recovery, and a high patients’ satisfactions without increasing morbidity.

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Satisfaction with prophylactic risk-reducing salpingo-oophorectomy in BRCA mutation carriers is very high and little dependent on the participants’ characteristics at surgery: a prospective study

Cited by 3 publications

References 28 publications

BRCA mutation carriers’ perceptions on postmenopausal hormone therapy: An Italian study

BRCA mutation carriers’ perceptions on postmenopausal hormone therapy: An Italian study

Sexual Function in Women Diagnosed with Hereditary Breast and Ovarian Cancer Syndrome

Risk-Reducing Salpingo-Oophorectomy (RRSO) Combined with Simultaneous Mastectomy in Women with BRCA 1–2 Mutation Carriers: The Surgical Technique, the Feasibility and Patients’ Satisfaction of Multiple Surgeries

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