Satisfaction and treatment adherence in erectile dysfunction in the medium and long term

Panach-Navarrete, Jorge; Morales-Giraldo, A.; Ferrandis-Cortes, C.; García-Morata, F.; Pastor-Lence, J.C.; Martínez-Jabaloyas, J.M.

doi:10.1016/j.acuroe.2017.03.005

Cited by 1 publication

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nowadays, oral phosphodiesterase isoenzyme-5 inhibitors (PDE5-Is) are considered the first-line therapy for erectile dysfunction (ED) [1] . Specifically, PDE5 hydrolyses cyclic cGMP to 5′-GMP by blocking cGMP hydrolysis, and potentiates the effects of cGMP resulting in decreased intracellular calcium leading to penile smooth muscle relaxation and vasodilatation with increased penile blood flow [2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

PDE -5 inhibitors’ implications in women: Are they of help?

Mostafa

2019

Human Andrology

View full text Add to dashboard Cite

Introduction: Introduction of the oral phosphodiesterase isoenzyme-5 inhibitors (PDE5-Is) has revolutionized sexual medicine by affording effective treatment for erectile dysfunction. PDE5 hydrolyses cyclic GMP specifically to 5′-GMP. Since its launching, PDE5-Is have stimulated scientific interest for their impending benefits in various implications for the welfare of the human beings. Aim: To highlight the possible potential implications of PDE5-Is in women. Participants and methods: A systematic review was carried out till June 2017 based on a search of concerned articles in Medline, medical subject heading databases, Scopus, The Cochrane Library, Embase, and CINAHL databases without language restriction. Keywords used to assess that outcome and concerned associations were PDE5 inhibitors, sildenafil, tadalafil, vardenafil, avanafil, women, and females. Main outcome measures: Different implications for PDE5-Is in women. Results: Oral PDE5-Is have beneficial medical implications in women. Sexual implications include female sexual dysfunction, female sexual arousal disorder, antidepressant-associated sexual dysfunction, and affected relationship. Gynecological implications include endometrial thickness, abortion, preeclampsia, fetal growth restriction, clitoral engorgement, primary dysmenorrhea, uterine blood flow, oligohydramnios, poor ovarian response, ovarian ischemia/reperfusion, and uterine contractility. Urological implications include overactive bladder and interstitial cystitis, whereas dermatological implications include systemic sclerosis and cellulite. In addition, PDE5-Is proved to be beneficial in pulmonary arterial hypertension, coronary dysfunction, esophageal motility, and some metabolic effects. Conclusion: Oral PDE5-Is are an eye-catching therapeutic class of agents with beneficial effects for women, which could be potentially applied after well-designed clinical trials.

show abstract

Section: Introductionmentioning

confidence: 99%

PDE -5 inhibitors’ implications in women: Are they of help?

Mostafa

2019

Human Andrology

View full text Add to dashboard Cite

show abstract

Satisfaction and treatment adherence in erectile dysfunction in the medium and long term

Cited by 1 publication

References 27 publications

PDE -5 inhibitors’ implications in women: Are they of help?

PDE -5 inhibitors’ implications in women: Are they of help?

Contact Info

Product

Resources

About