Satiety responses in eating disorders

Owen, William P.; Halmi, Katherine A.; Gibbs, James; Smith, Gerard P.

doi:10.1016/0022-3956(85)90029-9

Cited by 36 publications

(9 citation statements)

References 5 publications

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“…9,10,27,28 Furthermore, the results do not support the hypothesis that in eating disordered and in BED patients a low serum leptin concentration is a primary phenomenon, which causes a restriction of food intake in anorexia nervosa patients, 27 or an increased hunger sensation that compels bulimia nervosa or BED patients to binge. 29 Rather, increased or decreased serum leptin concentrations merely seem to be the consequence of prolonged periods of sharply negative energy balance ensuing from frequent dieting in anorectic patients or in restricting individuals, or of frequent bouts of positive energy balances due to bingeing episodes in BED and in bulimic patients.…”

Section: Discussionmentioning

confidence: 99%

Serum leptin concentration in obese patients with binge eating disorder

Adami

Campostano²,

Cella

et al. 2002

Int J Obes

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BACKGROUND:In steady-state conditions serum leptin concentration is directly related to body fat stores, but is also affected by changes in energy balance. This cross-sectional study investigated the serum leptin concentrations of severely obese patients with binge eating disorder (BED), in whom body fat was greater than normal and, because of eating pattern, rapid and repeated changes in energy balances took place. METHODS: A group of BED obese patients was compared to a group of obese patients with a regular eating pattern with the same body weight, body composition and resting energy expenditure. Serum leptin was measured and the eating attitudes were evaluated by Eating Inventory and Eating Disorder Inventory. RESULTS: In these patients serum leptin concentrations were only weakly correlated to body mass. Furthermore, in BED obese patients serum leptin concentration was higher than in their non bingeing counterparts. CONCLUSIONS: In obese patients both body fat size and eating behavior influence serum leptin concentration, but BED patients binge eating is not triggered by a low leptin value.

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Section: Discussionmentioning

confidence: 99%

Serum leptin concentration in obese patients with binge eating disorder

Adami

Campostano²,

Cella

et al. 2002

Int J Obes

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“…Laboratory test meals are usually smaller in AN than in controls (6–11), but under some test conditions they are equal (12) or even larger (13). Test meals in AN are lower in energy density (7), last longer (12), and contain more pauses and short eating bouts (12) compared with meals of women with BN and those without an eating disorder.…”

Section: Introductionmentioning

confidence: 99%

Modified sham feeding of sweet solutions in women with anorexia nervosa

Klein

Schebendach

Gershkovich

et al. 2010

Physiology & Behavior

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Anorexia Nervosa (AN) is a disorder of self-starvation characterized by decreased meal size and food intake. While it is possible that reduced food intake in AN reflects an excess of inhibitory factors, e.g., cognitive inhibition related to fear of weight gain or abnormal postingestive negative feedback, it is also possible that decreased intake reflects diminished orosensory stimulation of food intake. This has been difficult to test directly because the amount of food ingested during a test meal by patients with AN reflects an integration of orosensory excitatory, and cognitive, learned, and postingestive inhibitory controls of eating. To begin to dissociate these controls, we adapted the modified sham feeding technique (MSF) to measure the intake of a series of sweetened solutions in the absence of postingestive stimulation. Subjects with AN (n=24) and normal controls (NC, n=10) were randomly presented with cherry Kool Aid® solutions sweetened with five concentrations of aspartame (0, 0.01, 0.03, 0.08 and 0.28%) in a closed opaque container fitted with a straw. They were instructed to sip as much as they wanted of the solution during 15 1-minute trials and to spit the fluid out into another opaque container. Subjects with AN sipped less unsweetened solution than NC (p<0.05). Because this difference appeared to account completely for the smaller intakes of sweetened solutions by AN, responsiveness of intake to sweet taste per se was not different in AN and NC. Since MSF eliminated postingestive and presumably cognitive inhibitory controls, and the orosensory response to sweet taste was not different in AN than NC, we conclude that decreased intake by AN subjects under these conditions reflects the increased inhibition characteristic of this disorder that is presumably learned, with a possible contribution of decreased potency of orosensory stimulation by the sipped solutions.

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“…In bulimia and bulimia nervosa, abnormal per ception of interoceptive stimuli has been demonstrated by Robinson et al [42] and Owen et al [43]. who have shown that pa tients report hunger continuing after meals despite an associated sensation of fullness.…”

Section: Psychologicalmentioning

confidence: 93%