Satiated-efferocytosis: A novel functional property for resolution-phase macrophages regulated by glucocorticoids, resolvins, galectin-1 and the chemokine-scavenging receptor D6 (P4157)
Abstract:The engulfment of apoptotic leukocytes (efferocytosis) by macrophages during the resolution of inflammation is essential for homeostasis and results in macrophage reprogramming/immune-silencing. Here, we show CD11bhigh macrophages convert to CD11blow ones and stop efferocytosing apoptotic PMN after reaching an engulfment threshold in vivo. In addition, CD11blow macrophages are distinct from either M1 or M2 in their protein expression profile and display pro-resolving properties, such as diminished responses to… Show more
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