Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

Civita, Prospero; Ortenzi, Valerio; Naccarato, Antonio Giuseppe; Gumbleton, Mark; Pilkington, Geoffrey J.

doi:10.3390/cancers12123720

Cited by 11 publications

(3 citation statements)

References 112 publications

(101 reference statements)

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“…In two cases, loss of neurons and myelin near the Gaucher cells was observed. Varying degrees of neuronal loss, satellitosis (clustering of glia around neurons) [ 35 ], and neuronophagia were noted in all five patients. Light microscopy demonstrated lipofuscin with simple and complex lipids, but not glycolipids.…”

Section: Neuropathologic Findings In Neuronopathic Gdmentioning

confidence: 99%

Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism

Furderer

Hertz

Lopez

et al. 2022

IJMS

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Deficient acid β-glucocerebrosidase activity due to biallelic mutations in GBA1 results in Gaucher disease (GD). Patients with this lysosomal storage disorder exhibit a wide range of associated manifestations, spanning from virtually asymptomatic adults to infants with severe neurodegeneration. While type 1 GD (GD1) is considered non-neuronopathic, a small subset of patients develop parkinsonian features. Variants in GBA1 are also an important risk factor for several common Lewy body disorders (LBDs). Neuropathological examinations of patients with GD, including those who developed LBDs, are rare. GD primarily affects macrophages, and perivascular infiltration of Gaucher macrophages is the most common neuropathologic finding. However, the frequency of these clusters and the affected anatomical region varies. GD affects astrocytes, and, in neuronopathic GD, neurons in cerebral cortical layers 3 and 5, layer 4b of the calcarine cortex, and hippocampal regions CA2–4. In addition, several reports describe selective degeneration of the cerebellar dentate nucleus in chronic neuronopathic GD. GD1 is characterized by astrogliosis without prominent neuronal loss. In GD-LBD, widespread Lewy body pathology is seen, often involving hippocampal regions CA2–4. Additional neuropathological examinations in GD are sorely needed to clarify disease-specific patterns and elucidate causative mechanisms relevant to GD, and potentially to more common neurodegenerative diseases.

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Section: Neuropathologic Findings In Neuronopathic Gdmentioning

confidence: 99%

Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism

Furderer

Hertz

Lopez

et al. 2022

IJMS

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“…Perineuronal or neuronal satellitosis is the term describing the presence of glial cells in the satellite space, a 6-µm width space surrounding the neuronal perikaryon (Wohlsein et al, 2013). The presence of perineuronal glial cells as a normal finding in the central nervous system (CNS) was first described during the late 19th century and at the beginning of the 20th century by eminent researchers like Santiago Ramón y Cajal and Wilder Penfield (Brownson, 1956;Civita et al, 2020;Vijayan et al, 1993). In these years, the term "satellitosis" or "neuronal satellitosis" (NS) was specifically attributed to the increased number of perineuronal glial cells in the satellite space; first described as a normal and reactive "vitalizing-like phenomenon" (Brownson, 1956).…”

Section: Introductionmentioning

confidence: 99%

Neuronal satellitosis is a common finding in the avian brain

et al. 2022

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Perineuronal or neuronal satellitosis is the term describing the presence of glial cells in the satellite space surrounding the neuronal perikaryon. Confusingly, this finding has been described both as a physiologic and pathologic condition in humans and animals. In animals, neuronal satellitosis has been described in mammals, as well as in avian species. For the latter, the authors wondered whether neuronal satellitosis is expressed in the normal telencephalon of different avian orders and families and whether this pattern in different species shows a specific brain-region association. For these aims, this study explored the presence of neuronal satellitosis in the major areas of the healthy telencephalon in wild and domestic avian species of different orders and families, evaluating its grade in different brain regions. Neuronal satellitosis was seen in the hyperpallium and mesopallium as areas with the highest grade. Passeriformes showed the highest grade of neuronal satellitosis compared to diurnal or nocturnal raptors, and Charadriiformes. To clarify the exact role of neuronal satellitosis in animals without neurological disease, further studies are needed. RESEARCH HIGHLIGHTS. Neuronal satellitosis is a common finding in the healthy avian telencephalon.. Neuronal satellitosis is a species-and brain-region-associated finding in birds.. Passeriformes have the highest grade of neuronal satellitosis.

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“…4 Perineural satellitosis is characterized by invasion of the area surrounding neurons and perivascular satellitosis by infiltration of Virchow–Robin spaces surrounding blood vessels by neoplastic glial cells. 6 …”

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confidence: 99%

Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

van den Elshout,

Ariëns,

Blaauboer

et al. 2023

Neuro-Oncology Advances

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Background Survival outcomes for glioblastoma (GBM) patients remain unfavorable, and tumor recurrence is often observed. Understanding the radiological growth patterns of GBM could aid in improving outcome. This study aimed to examine the relationship between contrast-enhancing tumor growth direction and white matter, using an image registration and deformation strategy. Methods In GBM patients two pretreatment scans (diagnostic and neuronavigation) were gathered retrospectively, co-registered to a template and DTI atlas. The GBM lesions were segmented and co-registered to the same space. Growth vectors were derived and divided into vector populations parallel (Φ = 0-20 degrees) and perpendicular (Φ = 70-90 degrees) to white matter. To test for statistical significance between parallel and perpendicular groups, a paired samples Students T-test was performed. O6-methylguanine-DNA methyltransferase (MGMT) methylation status and its correlation to growth rate was also tested using a one-way ANOVA test. Results For 78 GBM patients (mean age 61 years ± 13 SD, 32 men), the included GBM lesions showed a predominant preference of perineural satellitosis (p<0.001), with a mean percentile growth of 30.8% (95CI 29.6% – 32.0%) parallel (0° < |Φ| <20°) to white matter. Perpendicular tumor growth with respect to white matter microstructure (70° < |Φ| <90°) showed to be 22.7% (95CI 21.3% – 24.1%) of total tumor growth direction. Conclusions The presented strategy showed that tumor growth direction in pretreatment GBM patients correlated with white matter architecture. Future studies with patient-specific DTI data are required to verify the accuracy of this method prospectively to identify its usefulness as a clinical metric in pre- and posttreatment setting.

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Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

Cited by 11 publications

References 112 publications

Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism

Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism

Neuronal satellitosis is a common finding in the avian brain

Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

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