Satellite cells in human skeletal muscle plasticity

Snijders, Tim; Nederveen, Joshua P.; McKay, Bryon R.; Joanisse, Sophie; Verdijk, Lex B.; Loon, Luc J. C. van; Parise, Gianni

doi:10.3389/fphys.2015.00283

Cited by 259 publications

(258 citation statements)

References 239 publications

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“…Although type I muscle fibres are smaller in size, a greater number of capillaries are associated with these oxidative fibres in young adults [6,7]. The progressive loss of muscle mass associated with aging, preferentially affects type II muscle fibres [8]. In addition to type II fibre atrophy, aging skeletal muscle is characterized by a loss of total number of muscle fibres, a shift towards a greater proportion of type I muscle fibres and fibre type grouping potentially due to denervation [8].…”

Section: Introductionmentioning

confidence: 99%

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

et al. 2016

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Sarcopenia is the age-related loss of skeletal muscle mass and strength. Ultimately, sarcopenia results in the loss of independence, which imposes a large financial burden on healthcare systems worldwide. A critical facet of sarcopenia is the diminished ability for aged muscle to regenerate, repair and remodel. Over the years, research has focused on elucidating underlying mechanisms of sarcopenia and the impaired ability of muscle to respond to stimuli with aging. Muscle-specific stem cells, termed satellite cells (SC), play an important role in maintaining muscle health throughout the lifespan. It is well established that SC are essential in skeletal muscle regeneration, and it has been hypothesized that a reduction and/or dysregulation of the SC pool, may contribute to accelerated loss of skeletal muscle mass that is observed with advancing age. The preservation of skeletal muscle tissue and its ability to respond to stimuli may be impacted by reduced SC content and impaired function observed with aging. Aging is also associated with a reduction in capillarization of skeletal muscle. We have recently demonstrated that the distance between type II fibre-associated SC and capillaries is greater in older compared to younger adults. The greater distance between SC and capillaries in older adults may contribute to the dysregulation in SC activation ultimately impairing muscle's ability to remodel and, in extreme circumstances, regenerate. This viewpoint will highlight the importance of optimal SC activation in addition to skeletal muscle capillarization to maximize the regenerative potential of skeletal muscle in older adults.

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Section: Introductionmentioning

confidence: 99%

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

et al. 2016

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“…They reenter the mitotic cell cycle and form new myofibers or fuse with damaged myofibers (Laumonier and Menetrey, 2016). Some of the cells reenter the G0 state and therefore are capable of maintaining the regenerative potential of injured muscle tissue (Dhawan and Rondo, 2005;Sinanan et al, 2006;Dumont et al, 2015;Snijders et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

An in vitro human skeletal muscle model: coculture of myotubes,neuron-like cells, and the capillary network

Ertan¹,

Kenar²,

Beyzadeoğlu³

et al. 2017

Turk J Biol

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This study reports the generation of a new human muscle tissue equivalent from skeletal muscle-derived stem cells and human umbilical vein endothelial cells (HUVECs). Skeletal muscle stem cells were isolated by the preplate technique and differentiated into neuron-like cells that were positive for neuronal beta-tubulin3 and nestin and negative for the astrocyte marker glial fibrillary acidic protein (GFAP). Coculture of skeletal muscle stem cells with the HUVECs under optimized fetal bovine serum and media conditions resulted in formation of a capillary network among the multinucleated myotubes. The neuron-like cells derived from the human skeletal muscle stem cells were seeded onto vascularized myotubes to obtain the neuromuscular junctions in the coculture. At the end of 24 h of coculture, the neuron-like cells were found to be in association with the myotubes. This model represents a novel complex in vitro human skeletal muscle model containing advanced capillary networks and interacting myotubes and neurons, and it can be used for in vitro drug testing or for skeletal muscle regeneration either through application of cellular therapy or cell-laden tissue-engineered muscle constructs.

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“…It has been defined the most reliable satellite cell marker for mouse model, and in the last years, has been applied, also, in human studies (Snijders et al, 2015). This marker is one of the most reliable concerning to satellite cell identification.…”

Section: Identification Of Satellite Cellsmentioning

confidence: 99%

“…However, NCAM/CD45 can be expressed in myoblasts, myotubes and muscle fibers during development/regeneration stages (Illa et al, 1992). To prevent this, alternative markers like M-cadherin (M-Cad), c-Met and Pax-7 has been preferred instead NCAM/ CD45 (Snijders et al, 2015).…”

Section: Identification Of Satellite Cellsmentioning

confidence: 99%

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Myogenic satellite cels: a brief review

Ribeiro¹,

Tavares²

2016

ARSPA

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A navegação consulta e descarregamento dos títulos inseridos nas Bibliotecas Digitais UC Digitalis, UC Pombalina e UC Impactum, pressupõem a aceitação plena e sem reservas dos Termos e Condições de Uso destas Bibliotecas Digitais, disponíveis em https://digitalis.uc.pt/pt-pt/termos.Conforme exposto nos referidos Termos e Condições de Uso, o descarregamento de títulos de acesso restrito requer uma licença válida de autorização devendo o utilizador aceder ao(s) documento(s) a partir de um endereço de IP da instituição detentora da supramencionada licença.Ao utilizador é apenas permitido o descarregamento para uso pessoal, pelo que o emprego do(s) título(s) descarregado(s) para outro fim, designadamente comercial, carece de autorização do respetivo autor ou editor da obra.Na medida em que todas as obras da UC Digitalis se encontram protegidas pelo Código do Direito de Autor e Direitos Conexos e demais legislação aplicável, toda a cópia, parcial ou total, deste documento, nos casos em que é legalmente admitida, deverá conter ou fazer-se acompanhar por este aviso. Myogenic satellite cels: a brief review Autor(es):Ribeiro, Eurico; Tavares, Paula ABSTRACTSkeletal muscle has an amazing capacity to adapt him self to physiological and external stress as well as several types of injury. This capacity of overcome the injuries induced changes of skeletal muscle are part of the so call plasticity of the tissue. There are several mechanisms involved in the regeneration and adaptation processes of skeletal muscle. Myogenic satellite cells have been known to play a key role is those events. Thus, among all the stem cells present in skeletal muscle, the satellite cells are crucial to repair and remodelling the injured skeletal muscle. In addition, there is considerable amount of information about these cells, however, some activation mechanisms are still to clarify as well as factors that can activate the myogenic satellite cells in skeletal muscle adaptations and/or injury. These brief review aims to present some facts related to myogenic satellite cells and their role in some conditions of skeletal muscle changes.

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Satellite cells in human skeletal muscle plasticity

Cited by 259 publications

References 239 publications

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

An in vitro human skeletal muscle model: coculture of myotubes,neuron-like cells, and the capillary network

Myogenic satellite cels: a brief review

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