Satellite cell pool expansion is affected by skeletal muscle characteristics

Macaluso, Filippo; Brooks, Naomi; Niesler, Carola U.; Myburgh, Kathryn H.

doi:10.1002/mus.23721

Cited by 13 publications

(10 citation statements)

References 31 publications

(82 reference statements)

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“…Our most important result was able to demonstrate that the treadmill training induced an increase in muscle fiber perimeter on both muscles as expected (Macaluso et al, 2013) and the periodontal disease process influenced negatively muscle hypertrophy.…”

Section: Discussionsupporting

confidence: 74%

“…www.efsupit.ro 578 data show that the treadmill training induced an increase in muscle fiber perimeter on both muscles as expected (Macaluso et al, 2013) and the periodontal disease process influenced negatively muscle hypertrophy. We showed that in our result what the type II muscle fibers were more susceptible to the effects of periodontal disease, since the gastrocnemius was the most affected.…”

Section: Discussionsupporting

confidence: 67%

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2017

JPES

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Objective: The goal of this study was to analyze the role of periodontal disease associated with physical exercise on inflammatory mediators and muscle hypertrophy. Materials and Methods: Wistar rats were divided into four experimental groups (n=6): sedentary and healthy (SH), trained and healthy (TH), sedentary with PD (SP) and trained with PD (TP). Animals were submitted to 30 days of PD induction (SP and TP) followed by an 8 week long treadmill exercise protocol (TH and TP). Blood samples were analyzed for interleukin serum levels and leukocyte count, while the tibialis anterior and gastrocnemius muscle underwent histomorphologic analysis. Results: Trained animals with periodontal disease showed a significant decrease on muscle fibers perimeter and anaerobic endurance throughout the exercise protocol. It was also observed that PD increases the IL-6, IL-10 and TNF-α serum levels and the neutrophils and eosinophils blood count, while the association between PD-physical exercises exacerbated the PD changes on leukocyte count. Conclusion: These data suggest that the association between the pro-inflammatory state induced by PD and the physical exercise load might play an important role on muscle hypertrophy.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 67%

Untitled

2017

JPES

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“…We observed that satellite cell content increased 2 days following a bout of LC, remained elevated at 27 days, and was unaffected by B2 of LC. Time‐course studies in human muscle have consistently demonstrated expansion of the satellite cell pool from 1 to 8 days post‐LC (37, 38). Previously, long‐term (28 days) persistence of the expanded satellite cell pool was noted following damaging electrical stimulation in human muscle (9).…”

Section: Discussionmentioning

confidence: 99%

Extracellular matrix remodeling and its contribution to protective adaptation following lengthening contractions in human muscle

et al. 2015

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This study determined the contribution of extracellular matrix (ECM) remodeling to the protective adaptation of human skeletal muscle known as the repeated-bout effect (RBE). Muscle biopsies were obtained 3 hours, 2 days, and 27 days following an initial bout (B1) of lengthening contractions (LCs) and 2 days following a repeated bout (B2) in 2 separate studies. Biopsies from the nonexercised legs served as controls. In the first study, global transcriptomic analysis indicated widespread changes in ECM structural, deadhesive, and signaling transcripts, 3 hours following LC. To determine if ECM remodeling is involved in the RBE, we conducted a second study by use of a repeated-bout paradigm. TNC immunoreactivity increased 10.8-fold following B1, was attenuated following B2, and positively correlated with LC-induced strength loss (r 2 = 0.45; P = 0.009). Expression of collagen I, III, and IV (COL1A1, COL3A1, CO-L4A1) transcripts was unchanged early but increased 5.7 6 2.5-, 3.2 6 0.9-, and 2.1 6 0.4-fold (P < 0.05), respectively, 27 days post-B1 and were unaffected by B2. Likewise, TGF-b signaling demonstrated a delayed response following LC. Satellite cell content increased 80% (P < 0.05) 2 days post-B1 (P < 0.05), remained elevated 27 days post-B1, and was unaffected by B2. Collectively, the data suggest sequential ECM remodeling characterized by early deadhesion and delayed reconstructive activity that appear to contribute to the RBE

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“…Subjects returned to the laboratory every 24 h for the next 3 days to have their muscle strength and soreness assessed. Studies in rodent, and to more limited extent, humans suggest that MRF expression increases 24 h following exercise (McKay et al, 2012 ; Macaluso et al, 2013 ; Yin et al, 2013 ). Likewise, although measurable increases in satellite cell content most likely peak at later time points (i.e., 48–72 h post-exercise), increases in satellite cell content in human muscle has been widely reported 24 h following eccentric exercise (Dreyer et al, 2006 ; O'Reilly et al, 2008 ; Cermak et al, 2013 ).…”

Section: Methodsmentioning

confidence: 99%

Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise

et al. 2014

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Optimal repair and adaptation of skeletal muscle is facilitated by resident stem cells (satellite cells). To understand how different exercise modes influence satellite cell dynamics, we measured satellite cell activity in conjunction with markers of muscle damage and inflammation in human skeletal muscle following a single work- and intensity-matched bout of eccentric (ECC) or concentric contractions (CON). Participants completed a single bout of ECC (n = 7) or CON (n = 7) of the knee extensors. A muscle biopsy was obtained before and 24 h after exercise. Functional measures and immunohistochemical analyses were used to determine the extent of muscle damage and indices of satellite cell activity. Cytokine concentrations were measured using a multiplexed magnetic bead assay. Isokinetic peak torque decreased following ECC (p < 0.05) but not CON. Greater histological staining of the damage marker Xin was observed in muscle samples of ECC vs. CON. Tenasin C immunoreactivity increased 15 fold (p < 0.01) following ECC and was unchanged following CON. The inflammatory cytokines interferon gamma-induced protein 10 (IP-10) and monocyte chemotactic protein 1 (MCP-1) increased pre- to post-ECC (4.26 ± 1.4 vs. 10.49 ± 5.8 pg/ml, and 3.06 ± 0.7 vs. 6.25 ± 4.6 pg/ml, respectively; p < 0.05). There was no change in any cytokine post-CON. Satellite cell content increased 27% pre- to post-ECC (0.10 ± 0.031 vs. 0.127 ± 0.041, respectively; p < 0.05). There was no change in satellite cell number in CON (0.099 ± 0.027 vs. 0.102 ± 0.029, respectively). There was no fiber type-specific satellite cell response following either exercise mode. ECC but not CON resulted in an increase in MyoD positive nuclei per myofiber pre- to post-exercise (p < 0.05), but there was no change in MyoD DNA binding activity in either condition. In conclusion, ECC but not CON results in functional and histological evidence of muscle damage that is accompanied by increased satellite cell activity 24 h post-exercise.

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Satellite cell pool expansion is affected by skeletal muscle characteristics

Abstract: Interindividual physiological characteristics affect SC pool expansion after a single bout of DHR and are influenced by VO₂max .

Cited by 13 publications

References 31 publications

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Extracellular matrix remodeling and its contribution to protective adaptation following lengthening contractions in human muscle

Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise

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