SATB2 is a novel biomarker and therapeutic target for cancer

Roy, Sitikantha; Shrivastava, Anju; Srivastav, Sudesh; Shankar, Sharmila; Srivastava, Rajendra

doi:10.1111/jcmm.15755

Cited by 28 publications

(38 citation statements)

References 63 publications

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“…TargetScan ( ) was used to search for candidate targets with potential miR-875 binding sites. It was observed that there was a common binding site between miR-875 and the 3′-untranslated region of SATB2, a tumor suppressor ( 23 ), which was further verified using a luciferase reporter assay ( Fig. 5A ).…”

Section: Resultsmentioning

confidence: 67%

Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Zhou

Chen²,

Ding

et al. 2021

Mol Med Rep

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Long non-coding RNAs (lncRNAs) are involved in the development and progression of a variety of diseases. However, the role of the lncRNA HLA complex group 11 (HCG11) in non-small cell lung cancer (NSCLC) remains unclear. The present study showed that the expression levels of HCG11 were reduced in tumor tissues compared with adjacent normal tissues, and similar results were obtained in experiments using lung cancer cell lines. Additionally, patients with high HCG11 expression had an increased survival rate compared with patients with low HCG11 expression. Further studies have shown that overexpression of HCG11 inhibited NSCLC cell proliferation in vitro and in vivo . Interestingly, it was observed that HCG11 expression was negatively associated with the expression levels of oncogenic microRNA-875 (miR-875) in patient specimens. Specifically, HCG11 served as a sponge of miR-875. Notably, it was determined that special AT-rich sequence-binding protein 2 (SATB2) was a direct target gene of miR-875, and overexpression of miR-875 largely abrogated the effects of HCG11 in NSCLC cells. In conclusion, HCG11 was shown to suppress the malignant properties of NSCLC cells by targeting a miR-875/SATB2 axis, and may therefore be a promising target for the treatment of NSCLC.

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Section: Resultsmentioning

confidence: 67%

Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Zhou

Chen²,

Ding

et al. 2021

Mol Med Rep

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“…HPNE cells were grown in a cell culture medium in the presence or absence of ethanol (10 mM and 100 mM) for 6 months. Studies have shown the role of SATB2 in chromatin remodelling and regulation of genes, which participate in cell growth, survival, differentiation, self‐renewal, and pluripotency 28–31,39 . We therefore examined the mechanism of ethanol‐induced EMT characteristics in HPNE cells by comparing the expression of SATB2 in HPNE control cells and ethanol‐transformed HPNE cells (HPNE/Ethanol).…”

Section: Resultsmentioning

confidence: 99%

“…Studies have shown the role of SATB2 in chromatin remodelling and regulation of genes, which participate in cell growth, survival, differentiation, self‐renewal, and pluripotency. 28 , 29 , 30 , 31 , 39 We therefore examined the mechanism of ethanol‐induced EMT characteristics in HPNE cells by comparing the expression of SATB2 in HPNE control cells and ethanol‐transformed HPNE cells (HPNE/Ethanol). As shown in Figures 1A 6‐month exposure of HPNE cells to ethanol had induced the expression of SATB2 gene.…”

Section: Resultsmentioning

confidence: 99%

Ethanol exposure of human pancreatic normal ductal epithelial cells induces EMT phenotype and enhances pancreatic cancer development in KC (Pdx1‐Cre and LSL‐Kras^G12D) mice

Roy

et al. 2021

J Cellular Molecular Medi

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Alcohol is a risk factor for pancreatic cancer. However, the molecular mechanism by which chronic alcohol consumption influences pancreatic cancer development is not well understood. We have recently demonstrated that chronic ethanol exposure of pancreatic normal ductal epithelial cells (HPNE) induces cellular transformation by generating cancer stem cells (CSCs). Here, we examined whether chronic ethanol treatment induces epithelial–mesenchymal transition in HPNE cells and promotes pancreatic cancer development in KC (Pdx1‐Cre, and LSL‐KrasG12D) mice. Our data demonstrate that chronic ethanol exposure of HPNE cells induces SATB2 gene and those cells became highly motile. Ethanol treatment of HPNE cells results in downregulation of E‐Cadherin and upregulation of N‐Cadherin, Snail, Slug, Zeb1, Nanog and BMI‐1. Suppression of SATB2 expression in ethanol‐transformed HPNE cells inhibits EMT phenotypes. KC mice fed with an ethanol‐containing diet show enhanced pancreatic cancer growth and development than those fed with a control diet. Pancreas isolated from KC mice fed with an ethanol‐containing diet show higher expression of stem cell markers (CD133, CD44, CD24), pluripotency‐maintaining factors (cMyc, KLF4, SOX‐2, and Oct‐4), N‐Cadherin, EMT‐transcription factors (Snail, Slug, and Zeb1), and lower expression of E‐cadherin than those isolated from mice fed with a control diet. Furthermore, pancreas isolated from KC mice fed with an ethanol‐containing diet show higher expression of inflammatory cytokines (TNF‐α, IL‐6, and IL‐8) and PTGS‐2 (COX‐2) gene than those isolated from mice fed with a control diet. These data suggest that chronic alcohol consumption may contribute to pancreatic cancer development by generating inflammatory signals and CSCs.

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“…In Figure 1, we present the facial features of several of the participants in this study. Given SATB2 differential expression in various cancers and its significant role in cancer initiation, progression, and metastasis, it has been postulated as an oncogene (Roy et al, 2020). In this study, no cancers or tumors were reported.…”

Section: Discussionmentioning

confidence: 99%

SATB2‐associated syndrome in adolescents and adults

Zárate

Bosanko

Caffrey

2021

American J of Med Genetics Pt A

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The goal of this study was to investigate the medical, communication, activities of daily living (ADLs), and mental health concerns affecting adolescents and adults with SATB2-associated syndrome (SAS). A comprehensive questionnaire was administered to the caregivers of 49 individuals 12 years or older with SAS (mean age was 19.4 years, range 12-37 years). For all individuals, medical records, including laboratory results, were reviewed. Most individuals required some degree of assistance for ADLs and none of the adults were able to live independently. Health status was qualified as excellent or very good in 61% of individuals. The most common medical problems were dental anomalies, with a significantly higher frequency of hypotonia and gastroesophageal reflux in younger individuals. Medical and surgical interventions were often required. Sixty-nine percent (n = 33) of individuals spoke 10 or fewer words. Autism (41%), anxiety (37%), and attention deficit disorder (37%) were common with one third of individuals receiving medical treatments for these diagnoses.While medical and developmental problems in individuals with SAS were similar to those previously reported, many of these are persistent into adolescence and adulthood. This study provides better guidance for the challenges facing adults with SAS and their families.

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SATB2 is a novel biomarker and therapeutic target for cancer

Cited by 28 publications

References 63 publications

Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Ethanol exposure of human pancreatic normal ductal epithelial cells induces EMT phenotype and enhances pancreatic cancer development in KC (Pdx1‐Cre and LSL‐Kras^G12D) mice

SATB2‐associated syndrome in adolescents and adults

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SATB2 is a novel biomarker and therapeutic target for cancer

Cited by 28 publications

References 63 publications

Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis

Ethanol exposure of human pancreatic normal ductal epithelial cells induces EMT phenotype and enhances pancreatic cancer development in KC (Pdx1‐Cre and LSL‐KrasG12D) mice

SATB2‐associated syndrome in adolescents and adults

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Ethanol exposure of human pancreatic normal ductal epithelial cells induces EMT phenotype and enhances pancreatic cancer development in KC (Pdx1‐Cre and LSL‐Kras^G12D) mice