SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation

Ahlfors, Helena; Limaye, Amita; Elo, Laura L.; Tuomela, Soile; Burute, Mithila; Gottimukkala, Kamal Vishnu P.; Notani, Dimple; Rasool, Omid; Galande, Sanjeev; Lahesmaa, Riitta

doi:10.1182/blood-2009-11-252205

Cited by 61 publications

(90 citation statements)

References 51 publications

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“…The expression of Gata3, Satb1, Nfil3, Maf, and Pparg was previously shown to be increased by STAT6 in primary human CD4 + T cells by blocking STAT6 with RNAi . Additionally, IL4 is known to increase the expression of Atf3 and Satb1 (Chen et al, 2003b;Ahlfors et al, 2010). Furthermore, SATB1 coordinates Th2 cell differentiation by positively regulating Gata3 (Notani et al, 2010).…”

Section: Th2 Cell-specific Tfs Are Positively Regulated By Stat6 and mentioning

confidence: 99%

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions

et al. 2016

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ABSTRACT. Data integration has become a useful strategy for uncovering new insights into complex biological networks. We studied whether this approach can help to delineate the signal transducer and activator of transcription 6 (STAT6)-mediated transcriptional network driving T helper (Th) 2 cell fate decisions. To this end, we performed an integrative analysis of publicly available RNA-seq data of Stat6-knockout mouse studies together with STAT6 ChIP-seq data and our own gene expression time series data during Th2 cell differentiation. We focused on transcription factors (TFs), cytokines, and cytokine receptors and delineated 59 positively and 41 negatively STAT6-regulated genes, which were used to construct a transcriptional network around STAT6. The network illustrates that important and well-known TFs for Th2 cell differentiation are positively regulated by STAT6 and act either as activators for Th2 cells (e.g., Gata3, Atf3, Satb1, Nfil3, Maf, and Pparg) or as suppressors for other Th cell subpopulations such as Th1 (e.g., Ar), Th17 (e.g., Etv6), or iTreg (e.g., Stat3 and Hif1a) cells. Moreover, our approach reveals 11 TFs (e.g., Atf5, Creb3l2, and Asb2) with unknown functions in Th cell differentiation. This fact together with the observed enrichment of asthma risk genes among those regulated by STAT6 underlines the potential value of the data integration strategy used here. Thus, our results clearly support the opinion that data integration is a useful tool to delineate complex physiological processes.

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Section: Th2 Cell-specific Tfs Are Positively Regulated By Stat6 and mentioning

confidence: 99%

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions

et al. 2016

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“…An alternative way to explore potential therapeutic targets is to elucidate the regulation mechanism of SATB1 itself during disease progression. IL-4 43,44 and/or polycomb group protein that inactivates acetylated histone H3K9 45 were previously defined as regulators of SATB1 expression. However, Mac-1 and Mac-2A cells lack IL-4 46,47 and did not respond to TSA treatment in terms of SATB1 expression.…”

Section: Satb1 Upregulation During Disease Progression Is Associated mentioning

confidence: 99%

SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30+ lymphoproliferative disease by repressing p21

Wei

Zhang

et al. 2014

Blood

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“…The actions of SATB1 and SATB2 are cell lineage-specific. SATB1 acts as a genome organizer and gene regulator essential for T cell differentiation (24,26,28,29,(32)(33)(34), erythroid development (35), and mammary epithelial transformation (36) and also facilitates gene silencing by modulating the expression of Xist in embryonic cells (37).…”

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confidence: 99%

SATB Homeobox Proteins Regulate Trophoblast Stem Cell Renewal and Differentiation

Asanoma

Kubota

Chakraborty

et al. 2012

Journal of Biological Chemistry

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Background: Trophoblast cells, the functional components of the placenta, are derived from multipotent trophoblast stem (TS) cells. Results: SATB homeobox proteins regulate the TS cell stem state through up-regulation of a stem-specific transcription factor, EOMES, and inhibition of trophoblast differentiation. Conclusion: SATB proteins regulate TS cell development. Significance: Understanding TS cell biology is crucial to determining processes underlying placental development.

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SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation

Cited by 61 publications

References 51 publications

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions

SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30+ lymphoproliferative disease by repressing p21

SATB Homeobox Proteins Regulate Trophoblast Stem Cell Renewal and Differentiation

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