SAT0568 Rheumatological manifestations in a series of patients with chikungunya fever

Abstract

Background: An epidemic of Chikungunya Fever (CF) spread throughout South America in 2014. The acute manifestation of CF typically consists of febrile arthritis. The burden of the chronic articular manifestations remains a public health issue affecting activities of daily life. There is a very important impact on quality of life in patients affected by CF, even at chronic phase. The long-term functional status may also be affected by CF. Objectives: To evaluate longitudinally the disability, Health Related Quality of Life (HRQOL) and functional status of patients with CF and analyze the clinical and epidemiological factors associated with different outcomes. Methods: Patients with clinical and demographic diagnosis of CF and persistent articular symptoms were evaluated in a cohort study between May 2016 and December 2016. HRQOL was rated by Short-Form 12 (SF-12) and the functional status was checked through Health Assessment Questionnaire (HAQ) and the Global Functional Status (GFS). Data were divided per weeks after disease onset and were analysed (Spearmans's correlation coefficient and Mann-Whitney test). Results: Sixty-five patients (58 females), mean age of 51.3 (±13.3) were assessed. As expected, a significant correlation between pain related scores and Physical Health Composite Scale Score (PCS), HAQ and GFS was found (p<0.05)). Edema and morning stiffness correlated with PCS, HAQ and GFS status from 4 to 20 weeks after disease onset (p<0.05). There was improvement in scores of all instruments used from 4-8 weeks of disease to 12-16 weeks of disease (table 1). The worst indices of PCS, Mental Health Composite Scale Score (MCS) and GFS were scored in the first month, mean scores of 30.07±5.77, 38.13±8.54 and 3.15±1.07 respectively. Higher HAQ values were demonstrated between 4 and 8 weeks after disease onset (mean score 1.87±0.82).

Factors Associated With Chronic Arthropathy And Rheumatological Diseases After Chikungunya Infection in Colombia: A Case-Control Study

“…The most frequent complication is chronic chikungunya arthropathy, which consists of severe polyarticular pain that persists for more than 3 months and affects 30% of infected individuals (3-7). The appearance of rheumatological conditions such as rheumatoid arthritis, inflammatory spondyloarthropathy, systemic lupus erythematosus, and Sjögren syndrome after infection has also been described (7)(8)(9)(10)(11)(12). On the other hand, in rhe general population there are associations between rheumatological diseases such as a higher probability of presenting with rheumatoid arthritis if there is a family history of systemic lupus erythematosus, Sjögren's syndrome, or polymyalgia rheumatica (13) as well as frequent joint involvement, some immunological markers, the response to immunosuppressive drugs, and in general the highest prevalence in women.…”

Sjögren’s Syndrome Associated with Chikungunya Infection: A Case Report

“…In a similar manner, patients who had previous rheumatological conditions may experience worsening of the symptoms of the disease after CHIKV infection [ 6 ]. In a large series of 202 CHIKV patients, there is a description of two (2.6%) cases of SS associated with this viral infection [ 7 ].…”