SAT0280 A ten-year survival analysis of filipino patients with systemic lupus erythematosus at the national kidney and transplant institute (philippines)

Abstract

BackgroundSystemic lupus erythematosus (SLE) is increasingly being diagnosed in our country. Despite the increasing number of patients, there are no studies describing their clinical profile at the time of diagnosis at the National Kidney and Transplant Institute (NKTI). This study aims to describe patients' initial clinical presentations, outcomes, and their survival rate within ten years.ObjectivesTo determine the ten-year survival rate and presenting clinical manifestations of Filipino patients first diagnosed with SLE at the National Kidney and Transplant Institute (NKTI)MethodsThis is a retrospective cohort study using chart review of patients first diagnosed with SLE in 2004 followed up in the next ten years.ResultsEighty-five patients were first diagnosed with SLE wherein their average age was 28.10 years old ±12.03, 34.12% had hypertension, and 74.12% with renal involvement. The patients' cumulative 10-year survival was 75% with average survival time of 9.84 years. Moreover, biopsy- proven lupus nephritis had significantly longer survival time (mean=10.57 years, p=0.006) while those with cardiopulmonary manifestations had shorter survival (mean=0.71 years, p=0.030) as well as those on hemodialysis (mean=8.82 years, p=0.040). Lastly, eleven patients (12.94%) expired during the study period with active diseases and infections as the common causes of mortality.ConclusionsThe 10-year survival rate of patients with systemic lupus erythematosus was 75% which was comparable to the findings from several countries. Although renal involvement was the most common initial manifestation, it did not significantly affect survival similar to prominent studies.Disclosure of InterestNone declared