“…The role of antibiotic therapy in the management of post-Streptococcal syndromes (PSS) is best established with acute rheumatic fever. The role of penicillin prophylaxis has been suggested in paediatric cases of streptococcus associated cPAN [ [2] , [3] , [4] , [5] , [6] , [7] ]. The same prophylactic treatment was also suggested when a few adult streptococcus related cPAN have been reported but those cases have had the first vasculitis attack during childhood [ 8 , 9 ].…”