Abstract:the treatment of refractory RA but experience with TNF-a antagonisers in JIA is limited. Objectives We report the use of Infliximab in 3 patients with systemic JIA and polyarthritis. Methods LS (18 yrs) and JD (11 yrs), girls with systemic-onset JIA at the age of 11 and 3, had persistent, destructive polyarthritis. AP (10 yrs), a boy with systemic-onset JIA at the age of 5 had persistent systemic activity as well as severe polyarthritis. All 3 failed NSAID, corticosteroids, (high-dose) MTX and CsA treatment an… Show more
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