SAT0046 Intra-articular CD1C-expressing myeloid dendritic cells from RA patients express increased levels of T cell-attracting chemokines and induce TH1, TH2, and TH17 cell activity
Abstract:Background
Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been implicated to play a crucial role in the regulation of tolerance and pro-inflammatory immune responses in many disease states, including rheumatoid arthritis (RA). Despite this, studies that have reported on the role of naturally occurring circulating mDCs in RA are scarce. Recently, CD1c+ mDCs from RA patients were suggested to migrate from the circulation to the joint where they exhibit a semi-matur… Show more
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