SAT0020 The citrullinome in tissue and biofluids of human and mouse origin

Abstract

ANCAs. Antigen discovery to determine the targets of these recombinant plasmablast antibodies is ongoing. Conclusions: Plasmablasts from patients with GPA in the RAVE trial were sequenced and antibody repertoires were generated. Clonal families of plasmablasts, including those expressing antibodies possessing shared CDR sequences across multiple patients, were identified and recombinantly expressed. None of the 24 antibodies bound to PR3, suggesting these are not ANCAs and are potentially novel autoantibodies. Identification of the antigen targets of these antibodies is ongoing.