SAT-379 Glomerulonephritis Histopathological Pattern Change

Abstract

in five patients (62.5%). The most common de novo GN in those with a known NKD was calcineurin (CNI) induced thrombotic microangiopathy (TMA) in five patients (62.5%) while the most common de novo GN in those with unknown NKD were IgA nephropathy (4, 26.7%) and FSGS (4, 26.7%). Renal allograft biopsy was done mostly for proteinuria (18, 56.3%) followed by deterioration in renal function (9, 28.1%). Biopsy was done 17.5 (AE15) months post-transplant with the minimum duration being as low as six days. The mean period of follow up of patients with denovo/recurrent GN (from the time of diagnosis) was 25.8(AE22.3) months. In patients with denovo CNI induced TMA, graft function improved after the withdrawal of CNI. Excluding the above subgroup of patients, the rate of decline in GFR in patients with recurrent/denovo GN over the mean follow up period was 0.39ml/min/month. Graft loss was observed in 8 patients with recurrent/denovo GN. Conclusions: Glomerulonephritis (GN) in the renal allograft recipient is not uncommon. Of the 548 patients, 6.4 % developed GN of which the most common was IgA nephropathy. The most common recurrent GN was IgA nephropathy while the most common de novo GN in those with a known NKD was calcineurin induced thrombotic microangiopathy while the most common de novo GN in those with unknown NKD were IgA nephropathy and FSGS.

Literature review of lupus nephritis From the Arabian Gulf region

“…[15][16][17][18][19][20][21][22][23][24][25][26][27] In some of these studies, LN was the most common cause of secondary glomerulonephritis (GN), constituting between approximately 36%-72% of all secondary GN cases. [15][16][17][18][19][20][21]27 The two studies conducted in Oman showed that LN was the most frequent glomerular disease, occurring in approximately 30%-36% of all patients who had an available renal biopsy. 23,26 Proportion of patients with SLE that develop LN.…”