SAT-271-Genetic risk factors for advanced alcoholic and non-alcoholic liver disease in the general population

Åberg, Fredrik; Puukka, Pauli; Sahlman, Perttu; Nissinen, Markku; Salomaa, Veikko; Männistö, Satu; Lundqvist, Annamari; Perola, Markus; Jula, Antti; Färkkilä, Martti

doi:10.1016/s0618-8278(19)31503-8

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Metabolic Drivers Of Liver Disease1

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2023

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“…In the presence of harmful alcohol consumption, advanced liver disease and related outcomes can be strongly predicted by the presence of MetS, particularly diabetes/insulin resistance and obesity (especially WHR). 67,44,68,57,64,69 Obesity is also associated with elevated mortality risk in individuals with alcoholic hepatitis. 70 However, when liver dysfunction worsens, obesity, dyslipidemia, and arterial hypertension can be masked by sarcopenia, dysfunctional synthesis, and vasodilatation, respectively.…”

Section: Metabolic Drivers Of Liver Diseasementioning

confidence: 99%