Abstract:Background
: Critically ill patients often develop multiple organ failure accompanied by profound metabolic and endocrine alterations. The pathogenesis is incompletely understood, but the development of cellular stress, including endoplasmic reticulum (ER) stress, might play a pivotal role (1). Indeed, markers of ER stress have been observed in critical illness, both in animal models and human patients, correlating with organ dysfunction (1). ER stress normally activates the unfolded protein respons… Show more
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