Sat-139 Dexmdetomidine Reduces Norepinephrine Requirements for Achieving Target Blood Pressure and Preserves Kidney Oxygenation in Septic Acute Kidney Injury

Abstract

neutrophil or M1 macrophage-mediated colitis. This protective effect was also associated with a reduction of systemic proinflammatory cytokines and increase of anti-inflammatory cytokine IL-10. More importantly, alteration of the gut microbiome in oral antibiotics fed mice was associated significantly increased number of CD4+ CD25+ Tregs and Foxp3 expression in cervical lymph node and spleen following IRI. Conclusions: Our data showed the critical role of the commensal gut microbiome in the development of kidney IRI injury as well as distant organ injury. Antibiotic modification of gut microbiome induced renoprotective effect is thought to be partially mediated by modulating peripheral and systemic immune response toward Treg mediated immune tolerance. Targeting the gut might offer a new paradigm in the prevention of treatment of AKI.