Sat-114 Assessment of Iron Status in Patients With Pre-Dialysis CKD in a Tertiary Hospital in North-Central Nigeria

Abstract

The mean age of the patients was 45.1(AE11.9) years (range of 22-80 years). There were 90 males and 60 females with male to female ratio of 1.5 : 1. The prevalence of CKD-MBD in the study population was 55.3%. Of this, 61 (73.5%) patients had low turnover bone disease while 22 (26.5%) patients had high turnover bone disease. Symptoms suggestive of CKD-MBD in the study population were bone pain and pruritus occuring in 36.7% and 13.3% of the study population, respectively but present in 34.9% and 12.0% of the CKD-MBD patients respectively. Other symptoms present in the study population included leg swelling in 126(84%), frothiness of urine in 123(82%), vomiting in 109(72.7%), facial puffiness in 102(68%), haematuria in 18(12%) and chest pain in 73(48.7%). The mean values for serum PTH, serum calcium, serum phosphate, alkaline phosphatase and Ca x P product among the CKD-MBD patients were 205.06AE112.6 pg/ml, 2.56AE0.73mmol/l, 1.63AE0.63mmol/l, 109.26AE65.57IU/L and 4.07AE1.28mmol 2 /l 2 , respectively but the values among non CKD-MBD patients were 123.08AE120.99pg/ml, 2.32AE0.46mmol/l, 1.54AE0.57mmol/l, 108.13AE51.84I U/L and 3.52AE1.32mmol 2 /l 2 , respectively. There was hypercalcaemia in 44.6%, hypocalcaemia in 26.0%, hypophosphataemia in 12.0% and hyperphosphataemia in 29.3% of the patients. High alkaline phosphatase was observed in 36.0% while 8.7% had low alkaline phosphatase. There was high calcium x phosphate product in 34.0% of the patients. Hypercalcaemia was the most common biochemical abnormality in this study occuring in 44.6% of the patients while only 6% of those with CKD-MBD had radiological features of CKD-MBD. Conclusions: The prevalence of CKD-MBD in our environment is high and low turnover bone disease is the commonest type.