SAT-066 Auto-Destruction of the Thyroid and Coexisting Glutamic Acid Decarboxylase Mediated Neurological Disease in an Adolescent: An Unusual Presentation of Autoimmunity
Abstract:BACKGROUND: Autoimmune thyroiditis (AT) is a common cause of acquired hypothyroidism in children characterized by lymphocytic thyroid infiltration. Sometimes gradual thyroid failure occurs due to apoptosis of thyroid cells. It may occur via apoptotic cytokines, ligands and receptors, including T regulatory cells, tumor necrosis factors etc. AT can coexist with other organ specific autoimmune conditions. Rarely neurological autoimmunity due to glutamic acid decarboxylase (GAD) antigen may be associated with AT.… Show more
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