Sat-010 Use of Point of Care Creatinine for Early Detection and Management of Community Acquired Acute Kidney Injury-Study Design

Abstract

between POC Cr and Lab Cr was very good, with Pearson correlation r¼0.956 (p<0.01). Figure 1A depicts a scatter diagram between POC Cr and Lab Cr for the total cohort (96 samples). Figure 1B is a scatter diagram restricted to samples with Lab Cr <200 umol/L (92 samples). POC Cr was higher than Lab Cr in 70 out of 96 samples. Mean bias was 27.2AE47.94 (minimum-50 maximum 245) umol/l. A Bland-Altman Plot for the total cohort (96 samples) is presented in Figure 2A. All 4 out of 96 values that were outside the limits of agreement (set at mean AE2 standard deviations) were for Lab Cr values >200 umol/L. A Bland-Altman Plot is presented for paired samples with Lab Cr values <200 umol/L in Figure 2B. Conclusions: POC Cr technology had good overall correlation with the reference laboratory assay. It demonstrated higher discordance at higher Cr values (>200 umol/L) and on average POC Cr values tended to be higher than Cr values measured by the reference laboratory assay. POC Cr can be used as a screening tool for detection of AKI taking into consideration the mean bias and the discordance with laboratory assay. The results of the evaluation were reviewed in a joint primary and secondary care AKI workshop at Port Harcourt Nigeria and a steering committee was formed to develop guidance for the use of POC Cr technology in conjunction with clinical judgement for early detection and management of community acquired AKI.