SAT-006 Efficacy and Safety of High-volume Hemofiltration (HVHF) in patients with Septic Shock and Acute Kidney Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract

The 57.6% prevalence of haemoglobinuria in children with AKI in our setting is high and institution of early measures to prevent kidney damage is key. Steps such as appropriate treatment of the underlying cause of illness and liberal fluid administration with or without alkalinisation of the urine may prevent kidney damage. There is need for health-care givers to be cautious with administering medications that precipitate haemolysis in the setting of G6PD deficiency and those acting through other mechanisms to induce haemolysis and/or cause direct damage to the kidneys such as, ceftriaxone and some other cephalosporins, some antimalarial drugs and herbal remedies. There is also need for a long-term followup especially in those with recurrent disease and creating public awareness.