Sasa quelpaertensis leaf extract mitigates fatigue and regulates the transcriptome profile in mice

Song, Hana; Jang, Mi; Lee, Ju Yeop; Ko, Hee-Chul; Hur, Sung‐Pyo; Kim, Se-Jae

doi:10.1007/s13258-018-0765-2

Cited by 5 publications

(1 citation statement)

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“…Muscle mass is the main determinant of muscle strength and strength and is closely related to an organism’s exercise endurance capacity . Histopathological examination of the gastrocnemius and skeletal muscle did not reveal significant lesions between the CON, EX, and EX-OCT groups (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Dietary Supplementation of Octacosanol Improves Exercise-Induced Fatigue and Its Molecular Mechanism

Zhou

Cao

et al. 2021

J. Agric. Food Chem.

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Several publications report that octacosanol (OCT) has different biological functions. This study was designed to evaluate the antifatigue effect and molecular mechanism of octacosanol (200 mg/(kg day)) in forced exercise-induced fatigue models of trained male C57BL/6 mice. Results showed that octacosanol ameliorated the mice's autonomic activities, forelimb grip strength, and swimming endurance, and the levels of liver glycogen (LG), muscle glycogen (MG), blood lactic acid (BLA), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were also regulated. Gene analysis results showed that treatment with OCT upregulated 29 genes, while 38 genes were downregulated in gastrocnemius tissue. Gene ontology (GO) analyses indicated that these genes enriched functions in relation to myofibril, contractile fiber, and calciumdependent adenosinetriphosphatase (ATPase) activity. Octacosanol supplementation significantly adjusted the messenger RNA (mRNA) and protein expression levels related to fatigue performance. Octacosanol has an observably mitigating effect in exerciseinduced fatigue models, and its molecular mechanism may be related to the regulation of tripartite motif-containing 63 (Trim63), periaxin (Prx), calcium voltage-gated channel subunit α1 H (Cacna1h), and myosin-binding protein C (Mybpc3) expression.

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Section: Resultsmentioning

confidence: 99%