Sasa borealis Stem Extract Attenuates Hepatic Steatosis in  High-Fat Diet-induced Obese Rats

Song, Yuno; Lee, Soo-Jung; Jang, Sun-Hee; Ha, Ji Hee; Song, Young Min; Ko, Yeoung-Gyu; Kim, Hong-Duck; Min, Wongi; Kang, Suk-Nam; Cho, Jae‐Hyeon

doi:10.3390/nu6062179

Cited by 18 publications

(12 citation statements)

References 35 publications

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“…Besides, other studies have shown that treatment with similar doses of extracts of plants can alter the induction of obesity or other associated conditions. For example, the study from Song et al (2014) demonstrated that the methanol extract from the stem of Sasa borealis (150 mg/kg) reduced the body weight and hepatic steatosis in rats made obese by a high-fat diet consumption. Kim et al (2014) showed that the treatment with the ethanol extract from the rhizomes of Boesenbergia pandurata (200 mg/kg) decreased the whole body and adipose pad weight of C57BL/6J mice submitted to a high-fat diet through activation of AMP-activated protein kinase and regulation of lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…For example, the study from Song et al (2014) demonstrated that the methanol extract from the stem of Sasa borealis (150 mg/kg) reduced the body weight and hepatic steatosis in rats made obese by a high-fat diet consumption. Kim et al (2014) showed that the treatment with the ethanol extract from the rhizomes of Boesenbergia pandurata (200 mg/kg) decreased the whole body and adipose pad weight of C57BL/6J mice submitted to a high-fat diet through activation of AMP-activated protein kinase and regulation of lipid metabolism. However, differences in species of animals, composition of extracts or via of administration do not permit a direct comparison between the studies.…”

Section: Discussionmentioning

confidence: 99%

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Administration of the aqueous extract of the stem bark of Hancornia speciosa Gomes (Apocynaceae) does not alter obesity induced by high-fat diet in mice

Luana¹,

Cercato²,

Pollyanna³

et al. 2016

J. Med. Plants Res.

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Ethnobotanical surveys have shown that the stem bark of Hancornia speciosa Gomes (Apocynaceae) is popularly used to treat obesity and diabetes. However, there is no experimental evidence that confirms such use. The present study investigated the effects of the aqueous extract of the stem bark of H. speciosa (AEHS) on the glycemic and adipogenic profiles of obese mice. Mice were divided into four groups that received standard diet (SD), standard diet plus AEHS (SDE), high-fat diet (HD) and high-fat diet plus AEHS (HDE). The administration of AEHS (in a concentration of 0.3 mg.mL-1. ad libitum in the drinking water) was performed for the last 8 weeks totaling a period of 18 weeks, in which the animals received the diets. Whole body weight, liquid intake and food consumption were measured during the entire experiment. Blood glucose levels, insulin sensitivity, glucose tolerance and adipose pads weight were evaluated. Animals from the HD group presented higher body weight in comparison to animals from the SD group. That was associated with insulin resistance and glucose intolerance, as well as increased blood glucose levels (p < 0.05) and weight of adipose tissue pad (p < 0.05), when compared to the SD group. The treatment with AEHS did not alter obesity induced by high-fat diet, because no significant difference was observed between the HD and the HDE groups in all of the parameters evaluated. These findings allowed the conclusion that AEHS does not reverse the alterations caused by high-fat diet in mice, what goes against the popular use.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Administration of the aqueous extract of the stem bark of Hancornia speciosa Gomes (Apocynaceae) does not alter obesity induced by high-fat diet in mice

Luana¹,

Cercato²,

Pollyanna³

et al. 2016

J. Med. Plants Res.

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“…Rapeseed is rich in phenolic compounds including: sinapic, salicylic, protocatechuic, p -hydroxybenzoic, gentisic, ferulic, p -coumaric, cinnamic, caffeic, and syringic acids, which are all presented in the OROs. Those phenolics are capable of reducing fatty acid synthesis by suppressing numerous lipogenic enzymes, such as FAS and ACC as well as lipogenic transcriptional factor SREBP1 [ 28 , 29 , 30 ], and promote hepatic lipid oxidation by stimulating the expression of PPARα [ 28 , 29 ]. The accumulation of cholesterol is also associated with the pathogenesis of NAFLD [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Optimized Rapeseed Oils Rich in Endogenous Micronutrients Protect High Fat Diet Fed Rats from Hepatic Lipid Accumulation and Oxidative Stress

Liu

Gao

et al. 2015

Nutrients

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Micronutrients in rapeseed exert a potential benefit to hepatoprotection, but most of them are lost during the conventional refining processing. Thus some processing technologies have been optimized to improve micronutrient retention in oil. The aim of this study is to assess whether optimized rapeseed oils (OROs) have positive effects on hepatic lipid accumulation and oxidative stress induced by a high-fat diet. Methods: Rats received experiment diets containing 20% fat and refined rapeseed oil or OROs obtained with various processing technologies as lipid source. After 10 weeks of treatment, liver was assayed for lipid accumulation and oxidative stress. Results: All OROs reduced hepatic triglyceride contents. Microwave pretreatment-cold pressing oil (MPCPO) which had the highest micronutrients contents also reduced hepatic cholesterol level. MPCPO significantly decreased hepatic sterol regulatory element-binding transcription factor 1 (SREBP1) but increased peroxisome proliferator activated receptor α (PPARα) expressions, and as a result, MPCPO significantly suppressed acetyl CoA carboxylase and induced carnitine palmitoyl transferase-1 and acyl CoA oxidase expression. Hepatic catalase (CAT) and glutathione peroxidase (GPx) activities as well as reduced glutathione (GSH) contents remarkably increased and lipid peroxidation levels decreased in parallel with the increase of micronutrients. Conclusion: OROs had the ability to reduce excessive hepatic fat accumulation and oxidative stress, which indicated that OROs might contribute to ameliorating nonalcoholic fatty liver induced by high-fat diet.

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“…[230,233] Kaempferol and its glycosides were reported to reduce the accumulation of adipose tissue and improve hyperlipidemia and diabetes in obese mice by increasing lipid metabolism through the down-regulation of PPARγ and SREBP-1c. [230,234] Berger et al reported that a 50 µM concentration of kaempferol has a distinct epigenetic activity by inhibiting HDACs. [235] This compound is able to induce apoptosis by decreasing the expression of Bcl-2 and increasing the expression of Bax.…”

Section: Catechinsmentioning

confidence: 99%

Polyphenols and their benefits: A review

Rasouli

Farzaei

Khodarahmi

2017

International Journal of Food Properties

294

259

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Let food be thy medicine and medicine be thy food" was expressed by Hippocrates more than 2000 years ago and the health benefits of natural food products have been considered for different goals since the ancient times. As natural phytochemicals, phenolic compounds (PCs) are a major class of semi-water-soluble compounds (from fruit and vegetable sources) with one or more benzene rings that are generally found in nature as glycosides. According to a review of the literature, food scientists have studied the many health benefits of these compounds against pernicious human diseases (HDs). Today, choosing a healthy diet has become an essential part of healthy living and fitness. Many studies have shown that people who follow a specific diet (especially polyphenol-rich diets) are at a low risk for a range of chronic diseases, such as obesity, diabetes, cancer, heart disease, etc. The present research is a comprehensive review of studies on PCs with a focus on HDs that seeks to find out why some PCs have received such considerable attention all over the world. Data were collected from the Scopus database and a hierarchical cluster analysis was used with Ward's method to analyze the data. The results showed that three countries most involved in research on PCs are USA, China, and India, and also found that quercetin, catechin, and kaempferol are the three most studied PCs. Cardiovascular diseases, cancer, obesity, diabetes, and infectious diseases are the major treatment targets for PCs. The review of the literature showed that these compounds share a common molecular mode of action against HDs. The Journal of Agriculture and Food Chemistry, Food Chemistry, PLOS ONE, and Planta Medica are also the most popular journals for covering original research on PCs. However, this study seeks to facilitate future studies on PCs through its findings.

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Sasa borealis Stem Extract Attenuates Hepatic Steatosis in High-Fat Diet-induced Obese Rats

Cited by 18 publications

References 35 publications

Administration of the aqueous extract of the stem bark of Hancornia speciosa Gomes (Apocynaceae) does not alter obesity induced by high-fat diet in mice

Administration of the aqueous extract of the stem bark of Hancornia speciosa Gomes (Apocynaceae) does not alter obesity induced by high-fat diet in mice

Optimized Rapeseed Oils Rich in Endogenous Micronutrients Protect High Fat Diet Fed Rats from Hepatic Lipid Accumulation and Oxidative Stress

Polyphenols and their benefits: A review

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