SARS CoV2 infection _The longevity study perspectives

Lio, Domenico; Scola, Letizia; Giarratana, Rosa Maria; Candore, Giuseppina; Colonna‐Romano, Giuseppina; Caruso, Calogero; Balistreri, Carmela Rita

doi:10.1016/j.arr.2021.101299

Cited by 28 publications

(30 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With these examples in mind, it is also recognized that people of extreme ages (nonagenarians and centenarians) often display profiles of healthy aging and are equipped to respond in a manner that is beneficial leading to positive outcomes after pathogen infection. As this does not describe all extreme older individuals, some experts in aging hypothesize that nonagenarians and centenarians may be categorized as high-performing or low-performing where those that are high-performing have genetic or immunological signatures that are advantageous for healthy aging [ 29 , 30 ]. These characteristics such as decreased inflammation and inflammatory mediators (such as decreased IL-6), increased telomere length, and deceased redox reactions are associated with the beneficial immune responses and improve the high-performing centenarian outcome to viral infection [30] , [31] , [32] .…”

Section: Discussionmentioning

confidence: 99%

“…As this does not describe all extreme older individuals, some experts in aging hypothesize that nonagenarians and centenarians may be categorized as high-performing or low-performing where those that are high-performing have genetic or immunological signatures that are advantageous for healthy aging [ 29 , 30 ]. These characteristics such as decreased inflammation and inflammatory mediators (such as decreased IL-6), increased telomere length, and deceased redox reactions are associated with the beneficial immune responses and improve the high-performing centenarian outcome to viral infection [30] , [31] , [32] . Immune responses and immune mediators including NK cell activity, neutrophil microbicidal activity, IL-1bet,a and TNF-alpha, which may be inflammatory as well, have also been associated with positive outcomes for centenarians [31] .…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the authors of this study found that loss of SARS-CoV-2 specificity in any of the immune arms to be more prominent in those over 65 and those experiencing more severe disease [35] . It would be of interest to investigate the three arms of immune memory in the oldest old age group to determine if there is evidence of immunological stability as suggested by Lio and colleagues in their discussion of immunity in nonagenarians and centenarians [30] .…”

Section: Discussionmentioning

confidence: 99%

“…At the time of the study initiation, we focused on people in their 90 s and 100 s in the long-term care facility as the outcome of infection in these age groups was of particular importance due the epidemiological modeling indicating increased case fatality rates. Since immune mediators are also of interest it would have been important to identify the profiles of specific cytokines such as IL-6 and TNF-alpha in these residents [ 30 , 32 ]. Due to the limited amount of sample we were able to receive from these frail individuals, we were not able to complete additional immune profiling.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Centenarians and extremely old people living with frailty can elicit durable SARS-CoV-2 spike specific IgG antibodies with virus neutralization functions following virus infection as determined by serological study

et al. 2021

View full text Add to dashboard Cite

Background The SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has led to more than 165 million COVID-19 cases and >3.4 million deaths worldwide. Epidemiological analysis has revealed that the risk of developing severe COVID-19 increases with age. Despite a disproportionate number of older individuals and long-term care facilities being affected by SARS-CoV-2 and COVID-19, very little is understood about the immune responses and development of humoral immunity in the extremely old person after SARS-CoV-2 infection. Here we conducted a serological study to investigate the development of humoral immunity in centenarians following a SARS-CoV-2 outbreak in a long-term care facility. Methods Extreme aged individuals and centenarians who were residents in a long-term care facility and infected with or exposed to SARS-CoV-2 were investigated between April and June 2020 for the development of antibodies to SARS-CoV-2. Blood samples were collected from positive and bystander individuals 30 and 60 days after original diagnosis of SARS-CoV-2 infection. Plasma was used to quantify IgG, IgA, and IgM isotypes and subsequent subclasses of antibodies specific for SARS-CoV-2 spike protein. The function of anti-spike was then assessed by virus neutralization assays against the native SARS-CoV-2 virus. Findings Fifteen long-term care residents were investigated for SARS-CoV-2 infection. All individuals had a Clinical Frailty scale score ≥5 and were of extreme older age or were centenarians. Six women with a median age of 98.8 years tested positive for SARS-CoV-2. Anti-spike IgG antibody titers were the highest titers observed in our cohort with all IgG positive individuals having virus neutralization ability. Additionally, 5 out of the 6 positive participants had a robust IgA anti-SARS-CoV-2 response. In all 5, antibodies were detected after 60 days from initial diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Centenarians and extremely old people living with frailty can elicit durable SARS-CoV-2 spike specific IgG antibodies with virus neutralization functions following virus infection as determined by serological study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Centenarians are considered a model of successful ageing (17,50,51). Therefore, supercentenarians, i.e.…”

mentioning

confidence: 99%

Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender

Ligotti

Aiello

Accardi

et al. 2021

Clinical and Experimental Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

Centenarians born before 1919 are resistant to COVID-19

et al. 2022

Self Cite

View full text Add to dashboard Cite

Although mortality from COVID-19 progressively increases with age, there are controversial data in the literature on the probability of centenarians dying from COVID-19. Moreover, it has been claimed that men in their 90s and 100s are more resilient than women. To gain insight into this matter, we analysed, according to gender, mortality data during the first year of pandemic of Sicilian nonagenarians and centenarians. We used mortality data from the 2019 as a control. The crude excess mortality between the two years was calculated. Data on deaths of Sicilian 90 + years show that, in line with what is known about the different response to infections between the two genders, oldest females are more resilient to COVID-19 than males. Moreover, centenarians born before 1919, but not “younger centenarians”, are resilient to COVID-19. This latter datum should be related to the 1918 Spanish flu epidemic, although the mechanisms involved are not clear.

show abstract

SARS CoV2 infection _The longevity study perspectives

Abstract: Graphical abstract

Cited by 28 publications

References 141 publications

Centenarians and extremely old people living with frailty can elicit durable SARS-CoV-2 spike specific IgG antibodies with virus neutralization functions following virus infection as determined by serological study

Centenarians and extremely old people living with frailty can elicit durable SARS-CoV-2 spike specific IgG antibodies with virus neutralization functions following virus infection as determined by serological study

Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender

Centenarians born before 1919 are resistant to COVID-19

Contact Info

Product

Resources

About