SARS-CoV-2 seroprevalence in high-risk health care workers in a Belgian general hospital: evolution from the first wave to the second

Wauthier, Loris; Delefortrie, Quentin; Eppe, Nicolas; Vankerkhoven, P.; Wolff, E; Dekeyser, Melanie; Cirriez, J.-M.; Grimmelprez, Alexandre

doi:10.1080/17843286.2021.2004349

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Data from sero-surveillance programmes implemented in England similarly showed a plateau in seropositivity in children between January and August 2021, followed by a large increase starting from September 2021, probably due to the deployment of the vaccination campaign [ 20 ]. Conversely, similar studies performed in adult cohorts consistently showed a substantial increase in seroprevalence rate of anti-SARS-CoV-2 antibodies [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 92%

Evolution of SARS-CoV-2 IgG Seroprevalence in Children and Factors Associated with Seroconversion: Results from a Multiple Time-Points Study in Friuli-Venezia Giulia Region, Italy

et al. 2022

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Data on the effective burden of the SARS-CoV-2 pandemic in the pediatric population are limited. We aimed at assessing the prevalence of SARS-CoV-2 IgG antibodies in children at three subsequent time-points. The study was conducted between January 2021 and July 2021 among children referring to the Research Institute for Maternal and Child Health “Burlo Garofolo” in Trieste, a referral regional hospital in Friuli Venezia Giulia, Italy. A multivariate analysis was conducted to assess factors independently associated with seroconversion. A total of 594 children were included. Anti-SARS-CoV-2 trimeric Spike protein IgG antibodies were found in 32 (15.4%) children tested in April-May and in 20 (11.8%) in June–July 2021, compared with 24 (11.1%) of those tested in January–February 2021 (p = 0.37, Armitage exact test for trend over time p = 0.76). A subgroup analysis and a multivariate logistic regression analysis were performed considering sociodemographic, clinical, and historical variables. Three categories of children showed statistically significant increased odds of positive anti-SARS-CoV-2 IgG antibodies: children previously positive to a nasopharyngeal swab (AdjOR 15.41, 95%CI 3.44–69.04, p < 0.001), cohabitant with a person with an history of a previous positive nasopharyngeal swab (AdjOR 9.95, 95%CI 5.35–18.52, p < 0.001), and children with a foreign citizenship (AdjOR 2.4, 95%CI 1.05–5.70, p = 0.002). The study suggests that seroprevalence studies may be of limited help in estimating the prevalence of the COVID-19 pandemic in children. Further studies are needed to identify other markers of previous SARS-CoV-2 infection in children, such as CD4+ T cells or memory B-cells.

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Section: Discussionmentioning

confidence: 92%

Evolution of SARS-CoV-2 IgG Seroprevalence in Children and Factors Associated with Seroconversion: Results from a Multiple Time-Points Study in Friuli-Venezia Giulia Region, Italy

et al. 2022

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“…The lack of substantive findings associated with activities thought initially to be at high risk (see Supporting Information: ) is in line with observations in other studies. There was no excess risk associated with work in an intensive care unit, 6,21,26–28 an emergency room 26 or with aerosol‐generating medical procedures, 6,22 even in the early unvaccinated phase, although small numbers limited the degree of certainty associated with such negative findings. The lack of protection from screening patients for infection and providing a “buddy” to help with donning and doffing PPE is also worth noting.…”

Section: Discussionmentioning

confidence: 98%

The evolution of workplace risk for Covid‐19 in Canadian healthcare workers and its relation to vaccination: A nested case‐referent study

Cherry

Mhonde

Adisesh

et al. 2023

American J Industrial Med

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Background During the early months of the Covid‐19 pandemic, studies demonstrated that healthcare workers (HCWs) were at increased risk of infection. Few modifiable risks were identified. It is largely unknown how these evolved over time. Methods A prospective case‐referent study was established and nested within a cohort study of Canadian HCWs. Cases of Covid‐19, confirmed by polymerase chain reaction, were matched with up to four referents on job, province, gender, and date of first vaccination. Cases and referents completed a questionnaire reporting exposures and experiences in the 21 days before case date. Participants were recruited from October 2020 to March 2022. Workplace factors were examined by mixed‐effects logistic regression allowing for competing exposures. A sensitivity analysis was limited to those for whom family/community transmission seemed unlikely. Results 533 cases were matched with 1697 referents. Among unvaccinated HCWs, the risk of infection was increased if they worked hands‐on with patients with Covid‐19, on a ward designated for care of infected patients, or handled objects used by infected patients. Sensitivity analysis identified work in residential institutions and geriatric wards as high risk for unvaccinated HCWs. Later, with almost universal HCW vaccination, risk from working with infected patients was much reduced but cases were more likely than referents to report being unable to access an N95 mask or that decontaminated N95 masks were reused. Conclusions These results suggest that, after a rocky start, the risks of Covid‐19 infection from work in health care are now largely contained in Canada but with need for continued vigilance.

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“…According to the World Health Organization (WHO), one out of every seven COVID-19 patients (14%) is an HCW [15]. In this study, we estimated the seroprevalence of HCWs in the first wave as lower than those in most of studies from West European countries published to date, which were conducted in highly impacted countries during the first pandemic wave [16][17][18]. A pooled seroprevalence from the United States, ten European, and three East Asian countries was estimated as 8.6% (95%CI = 7.2-9.9%) [19].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Seroprevalence in Healthcare Workers before the Vaccination in Poland: Evolution from the First to the Second Pandemic Outbreak

Korona-Głowniak

Mielnik

Podgajna

et al. 2022

IJERPH

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Healthcare workers (HCWs) are on the frontline, struggling with the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To describe recent or past infections, the serological assays enabled the assessment of the immune response developed in coronavirus disease (COVID-19) in the period when testing was hardly available. In this study, we investigated SARS-CoV-2 seroprevalence in HCWs in a Polish teaching hospital and the Regional Occupational Medicine Center after both the first and the second waves. ELISA-based tests for anti-SARS-CoV-2 IgA and IgG were used to determine immune response to SARS-CoV-2 in volunteer HCWs who worked in those institutions in May 2020 (208 participants aged 47.1 ± 12.5, 88% women) and in December 2020 (179 participants aged 45.2 ± 12.4, 86% woman). Risk factors for seropositivity were also assessed using a questionnaire filled out by all participants. We reported a significant increase in seroprevalence after the second wave (22.9%) compared with the first outbreak (2.4%) (OR 12.1; 95%CI 4.6–31.3; p < 0.0001). An association between IgG seroprevalence and severity of infections was noted. Furthermore, we demonstrated that amongst medical personnel, nurses exhibited a proportionally higher SARS-CoV-2 seroprevalence. Moreover, given the high seroprevalence in non-clinical group of HCWs, we suggest that community transmission can play a superior role to workplace exposure.

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SARS-CoV-2 seroprevalence in high-risk health care workers in a Belgian general hospital: evolution from the first wave to the second

Cited by 5 publications

References 29 publications

Evolution of SARS-CoV-2 IgG Seroprevalence in Children and Factors Associated with Seroconversion: Results from a Multiple Time-Points Study in Friuli-Venezia Giulia Region, Italy

Evolution of SARS-CoV-2 IgG Seroprevalence in Children and Factors Associated with Seroconversion: Results from a Multiple Time-Points Study in Friuli-Venezia Giulia Region, Italy

The evolution of workplace risk for Covid‐19 in Canadian healthcare workers and its relation to vaccination: A nested case‐referent study

SARS-CoV-2 Seroprevalence in Healthcare Workers before the Vaccination in Poland: Evolution from the First to the Second Pandemic Outbreak

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