SARS-CoV-2 seroprevalence and antibodies persistence among health care workers after the first COVID-19 wave in nine hospitals in Western France

Garlantézec, Ronan; Tadié, Émilie; Heslan, Christopher; P, Gary-Bobo; Oumari, Sitty; Saade, Anastasia; Sitruk, Anaïs; Tattevin, Pierre; Thibault, Vincent; Paris, Christophe; Deun, Paule Le; Haberbusch, Marc; Guyader, Annie Le; Quiboeuf, Gilles; Garzic, Yves Le; Chauvel, Nicolas; Verley, Laurent; Goubert-Fauqueur, Laetitia

doi:10.1016/j.idnow.2022.09.004

Cited by 1 publication

(5 citation statements)

References 16 publications

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“…Our results suggest that PHCWs were not at higher risk of SARS-CoV-2 infection than the general adult population (19–64 years old) over the first eighteen months of the pandemic. These findings are consistent with some studies 4 , 6 , 7 but conflicting with others 5 . The discrepancies in results may be explained by the study periods.…”

Section: Discussionsupporting

confidence: 88%

“…This is in line with several previous studies 10 , 13 . Many authors reported a strong positive association between SARS-CoV-2 infection and being in contact with a COVID-19 case at home, including in Switzerland (aOR, 7.79; 95% CI, 5.98–10.15) 9 , in France (aOR 2.00; 95% CI 2.23–3.28) and in Belgium (aOR 3.15; 95% CI 2.33–4.25) 7 , 14 . In contrast to some studies conducted among hospital HCWs 7 , but consistent with others 10 , 11 , we did not find associations between the SARS-CoV-2 infection and workplace factors (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Many authors reported a strong positive association between SARS-CoV-2 infection and being in contact with a COVID-19 case at home, including in Switzerland (aOR, 7.79; 95% CI, 5.98–10.15) 9 , in France (aOR 2.00; 95% CI 2.23–3.28) and in Belgium (aOR 3.15; 95% CI 2.33–4.25) 7 , 14 . In contrast to some studies conducted among hospital HCWs 7 , but consistent with others 10 , 11 , we did not find associations between the SARS-CoV-2 infection and workplace factors (i.e. number of days worked, care of patients, test performance and PPE use during the first lockdown) in multivariate analysis, albeit two of them were significant in bivariate analyses (higher levels of infection for PHCWs not working exclusively in primary care and for those who were not wearing FFP2 or surgical mask every day during the first lockdown).…”

Section: Discussionmentioning

confidence: 99%

“…number of days worked, care of patients, test performance and PPE use during the first lockdown) in multivariate analysis, albeit two of them were significant in bivariate analyses (higher levels of infection for PHCWs not working exclusively in primary care and for those who were not wearing FFP2 or surgical mask every day during the first lockdown). In France, previous studies reported that close or prolonged contact with patients, aerosol-generating procedures, and performance of upper respiratory tract samples were associated with SARS-CoV-2 infection 7 . Discordance in results might be explained by different study populations, as those studies were conducted among HCWs from hospitals (some served as a referral center for COVID-19 during the first wave).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed substantial variability in prevalence and risk factors for SARS-CoV-2 infection among HCWs, attributed to different job roles, exposure to COVID-19 patient, access to PPE, data collection periods, and community prevalence 3 , 4 . Some studies reported a higher risk (between two- and seven-fold) of infection among HCWs from hospital or other healthcare settings than in the general population 5 , while others have not found such differences 4 , 6 , 7 . While some authors reported a dose–response association between COVID-19-patient exposure and the risk of SARS-CoV-2 infection 8 , 9 , others showed that community exposure was associated with infection but workplace factors were not 10 – 12 .…”

Section: Introductionmentioning

confidence: 99%

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SARS-CoV-2 infection prevalence and associated factors among primary healthcare workers in France after the third COVID-19 wave

Pouquet,

Decarreaux,

Di Domenico

et al. 2024

Sci Rep

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Data on the SARS-CoV-2 infection among primary health care workers (PHCWs) are scarce but essential to reflect on policy regarding prevention and control measures. We assessed the prevalence of PHCWs who have been infected by SARS-CoV-2 in comparison with modeling from the general population in metropolitan France, and associated factors. A cross-sectional study was conducted among general practitioners (GPs), pediatricians, dental and pharmacy workers in primary care between May and August 2021. Participants volunteered to provide a dried-blood spot for SARS-CoV-2 antibody assessment and completed a questionnaire. The primary outcome was defined as the detection of infection-induced antibodies (anti-nucleocapsid IgG, and for non-vaccinees: anti-Spike IgG and neutralizing antibodies) or previous self-reported infection (positive RT-qPCR or antigenic test, or positive ELISA test before vaccination). Estimates were adjusted using weights for representativeness and compared with prediction from the general population. Poisson regressions were used to quantify associated factors. The analysis included 1612 PHCWs. Weighted prevalences were: 31.7% (95% CI 27.5–36.0) for GPs, 28.7% (95% CI 24.4–33.0) for pediatricians, 25.2% (95% CI 20.6–31.0) for dentists, and 25.5% (95% CI 18.2–34.0) for pharmacists. Estimates were compatible with model predictions for the general population. PHCWs more likely to be infected were: GPs compared to pharmacist assistants (adjusted prevalence ratio [aPR] = 2.26; CI 95% 1.01–5.07), those living in Île-de-France (aPR = 1.53; CI 95% 1.14–2.05), South-East (aPR = 1.57; CI 95% 1.19–2.08), North-East (aPR = 1.81; CI 95% 1.38–2.37), and those having an unprotected contact with a COVID-19 case within the household (aPR = 1.48; CI 95% 1.22–1.80). Occupational factors were not associated with infection. In conclusion, the risk of SARS-CoV-2 exposure for PHCWs was more likely to have occurred in the community rather than at their workplace.

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