SARS-CoV-2-related pangolin coronavirus exhibits similar infection characteristics to SARS-CoV-2 and direct contact transmissibility in hamsters

A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation

“…Omicron is seen as more infectious as the result of its unusually low PID M . At least two laboratories [ 44 , 45 ] have also experimentally discovered that the 2017 pangolin-CoV is attenuated, as seen in Figure 7 .…”

“…In this paper, correlations with statistical significance are presented using more complete data available from [ 43 ]. Furthermore, data showing the viral titer of pangolin-CoV-2017 in comparison to that of SARS-CoV-2 were not available then [ 44 , 45 ]. Additionally, shell disorder analysis was yet to be performed on the COVID-19-related sequence obtained from bats in Laos [ 7 ].…”

Appearance and re-appearance of zoonotic disease during the pandemic period: long-term monitoring and analysis of zoonosis is crucial to confirm the animal origin of SARS-CoV-2 and monkeypox virus

“…Griffin et al reported that the North American deer mouse might be another host of SARS-CoV-2 (Griffin et al 2021 ). Guo et al reported that the hamsters are additional hosts of SARS-CoV-2 (Guo et al 2022 ). Thus, it might create the ambiguities surrounding the animal origin of COVID-19 that continues to puzzle the scientific community at large.…”

The nervous system during COVID‐19: Caught in the crossfire

“… 170 , 183 , 187 As in humans, low levels of SARS‐CoV‐2 (A‐D) can be detected on occasion in the brains of non‐human primates 37 , 186 and ferrets. 40 , 43 SARS‐CoV‐2 (A‐D) RNA is plentiful in the brains of young hamsters 36 , 53 , 175 but has yet to be detected in the brains of infected standard laboratory adult mice 137 , 138 , 188 and adult hamsters. 53 Further research is needed to assess whether SARS‐CoV‐2 RNA can be detected in the brains of aged rodents to recapitulate human disease.…”

“…34,35 Such a polybasic site has never been detected in pangolin-derived sarbecoronaviruses thus far, which may explain why pangolin-derived sarbecoronaviruses fail to be transmitted through aerosol and replicate efficiently in other mammalian hosts. 36 Therefore, the natural acquisition of SARS-CoV-2's polybasic site remains a mystery, and the lack of data on SARS-like sarbecoronavirus carrying this polybasic site leaves room for conspiracies of SARS-CoV-2 being initially created in a laboratory setting. 7,27 The mutation-dependent evolutionary plasticity of SARS-like sarbecoronaviruses binding ACE2 orthologs is remarkable, which explains the high zoonotic capabilities of these viruses.…”