SARS-CoV-2 prevalence in domestic and wildlife animals: A genomic and docking based structural comprehensive review

Das, Tuhin; Sikdar, Suranjana; Chowdhury, Md. Helal Uddin; Nyma, Khandakar Jannatul; Adnan, Md.

doi:10.1016/j.heliyon.2023.e19345

Cited by 5 publications

(3 citation statements)

References 156 publications

(178 reference statements)

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“…Bat feces may be effective vectors and natural reservoirs for many infectious viruses, bacteria, and fungi. Bats are known to be natural hosts of many zoonotic viruses and may be responsible for numerous outbreaks, including the ongoing COVID-19 pandemic [21]. In addition, bat feces are optimal substrates for the propagation and spread of fungi, including pathogenic histoplasmosis and fatal cryptococcosis [22].…”

Section: Discussionmentioning

confidence: 99%

Pharmaceutical Screening of Bat Feces and Their Applications and Risks in Traditional Chinese Medicine

Chung,

Lin,

Chuang

et al. 2024

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Bat feces have been reported in traditional Chinese medicine (TCM) books to have the effect of reducing fever and improving eyesight, but the mechanism of vision improvement still needs further research. To this end, we used 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and liquid chromatography/tandem mass spectrometry (LC/MS/MS) to analyze the antioxidant capacity of and the types of vitamins in bat feces. We hoped to screen the pharmacological components of bat feces and to explain the role that these components may play in treating visual deterioration. Our results found that bat feces had a good antioxidant capacity and mainly contained vitamins B1 (thiamine), B2 (riboflavin), B3 (nicotinamide), B3 (nicotinic acid), and B5 (pantothenic acid). Although these vitamins may help to maintain the health of the optic nerve and cornea, the vitamin content of bat feces is low, but the heavy metal content is high, as shown using inductively coupled plasma–mass spectrometry (ICP-MS) analysis. Therefore, we suggest that the use of bat feces as TCM to improve vision should be strictly restricted.

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Section: Discussionmentioning

confidence: 99%

Pharmaceutical Screening of Bat Feces and Their Applications and Risks in Traditional Chinese Medicine

Chung,

Lin,

Chuang

et al. 2024

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“…The SARS-CoV-2 is the seventh human pathogenic coronavirus among the other six related species namely 229E, NL63, OC43, HKU1, MERS-CoV (Middle East Respiratory Syndrome Coronavirus), and SARS-CoV 3 . The literature review reveals that the cross-species and human-to-human transmission of the virus is regulated by spike protein receptor-binding domain (RBD) and its host receptor (ACE2) similar to SARS-CoV caused a viral outbreak in 2002 4 – 8 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in silico inhibitory action studies of azo-anchored imidazo[4,5-b]indole scaffolds against the COVID-19 main protease (Mpro)

Geedkar,

Kumar,

Sharma

2024

Sci Rep

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The present work elicits a novel approach to combating COVID-19 by synthesizing a series of azo-anchored 3,4-dihydroimidazo[4,5-b]indole derivatives. The envisaged methodology involves the l-proline-catalyzed condensation of para-amino-functionalized azo benzene, indoline-2,3-dione, and ammonium acetate precursors with pertinent aryl aldehyde derivatives under ultrasonic conditions. The structures of synthesized compounds were corroborated through FT-IR, 1H NMR, 13C NMR, and mass analysis data. Molecular docking studies assessed the inhibitory potential of these compounds against the main protease (Mpro) of SARS-CoV-2. Remarkably, in silico investigations revealed significant inhibitory action surpassing standard drugs such as Remdesivir, Paxlovid, Molnupiravir, Chloroquine, Hydroxychloroquine (HCQ), and (N3), an irreversible Michael acceptor inhibitor. Furthermore, the highly active compound was also screened for cytotoxicity activity against HEK-293 cells and exhibited minimal toxicity across a range of concentrations, affirming its favorable safety profile and potential suitability. The pharmacokinetic properties (ADME) of the synthesized compounds have also been deliberated. This study paves the way for in vitro and in vivo testing of these scaffolds in the ongoing battle against SARS-CoV-2.

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“…Natural and experimental infections by SARS-CoV-2 have been described in a wide variety of animal hosts. Ferrets and cats were found to be highly susceptible to the virus, while dogs are less susceptible, and chickens, ducks, and pigs have shown lower susceptibility [ 25 , 26 ]. The free-ranging white-tailed deer has also been shown to be highly susceptible to SARS-CoV-2 virus infection and capable of sustaining transmission in nature [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Co-Circulation of Multiple Coronavirus Genera and Subgenera during an Epizootic of Lethal Respiratory Disease in Newborn Alpacas (Vicugna pacos) in Peru: First Report of Bat-like Coronaviruses in Alpacas

Llanco,

Retamozo,

Oviedo

et al. 2023

Animals

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Coronaviruses (CoVs) infect a wide range of hosts, including humans, domestic animals, and wildlife, typically causing mild-to-severe respiratory or enteric disease. The main objective of this study was to identify CoV genera and subgenera detected in Peruvian alpacas. Lung lavage specimens were collected from 32 animals aged 1 to 6 weeks. CoVs were identified by using RT-PCR to amplify a pan-CoV conserved region of the RNA-dependent RNA polymerase-encoding gene. A nested PCR was performed to identify β-CoVs. Then, β-CoV-positive samples were subjected to RT-PCR using specific primers to identify the Embecovirus subgenus. Out of 32 analyzed samples, 30 (93.8%) tested positive for at least one CoV genus. β-, α-, or unclassified CoVs were identified in 24 (80%), 1 (3.3%), and 1 (3.3%) of the positive samples, respectively. A CoV genus could not be identified in two (6.7%) samples. A mixture of different CoV genera was detected in two (6.7%) samples: one was co-infected with β- and α-CoVs, and the other contained a β- and an unclassified CoV. A sequence analysis of the amplicons generated by the PCR identified 17 β-CoV strains belonging to the subgenus Embecovirus and two α-CoV strains belonging to Decacovirus. A phylogenetic analysis of two strains revealed a relationship with an unclassified Megaderma BatCoV strain. A subgenus could not be identified in nine β-CoV samples. Our data show a high prevalence and a high genetic diversity of CoV genera and subgenera that infect alpacas, in which the β-CoV subgenus Embecovirus predominated. Our data also suggest a new role for bats in the dissemination and transmission of uncommon CoVs to alpacas raised in rural Peru.

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SARS-CoV-2 prevalence in domestic and wildlife animals: A genomic and docking based structural comprehensive review

Cited by 5 publications

References 156 publications

Pharmaceutical Screening of Bat Feces and Their Applications and Risks in Traditional Chinese Medicine

Pharmaceutical Screening of Bat Feces and Their Applications and Risks in Traditional Chinese Medicine

Synthesis and in silico inhibitory action studies of azo-anchored imidazo[4,5-b]indole scaffolds against the COVID-19 main protease (Mpro)

Co-Circulation of Multiple Coronavirus Genera and Subgenera during an Epizootic of Lethal Respiratory Disease in Newborn Alpacas (Vicugna pacos) in Peru: First Report of Bat-like Coronaviruses in Alpacas

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