2022
DOI: 10.1007/s00011-022-01683-y
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SARS-CoV-2-mediated liver injury: pathophysiology and mechanisms of disease

Abstract: Background SARS-CoV-2-induced severe inflammatory response can be associated with severe medical consequences leading to multi-organ failure, including the liver. The main mechanism behind this assault is the aggressive cytokine storm that induces cytotoxicity in various organs. Of interest, hepatic stellate cells (HSC) respond acutely to liver injury through several molecular mechanisms, hence furthering the perpetuation of the cytokine storm and its resultant tissue damage. In addition, hepatocy… Show more

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Cited by 5 publications
(3 citation statements)
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“…Several mechanisms may account for the onset and progression of liver damage in COVID-19 [16,[70][71][72]. For example, SARS-CoV-2 RNA and viral particles have been de-Life 2023, 13, 1324 9 of 13 tected in the liver parenchyma of patients with COVID-19 [73][74][75].…”
Section: Discussionmentioning
confidence: 99%
“…Several mechanisms may account for the onset and progression of liver damage in COVID-19 [16,[70][71][72]. For example, SARS-CoV-2 RNA and viral particles have been de-Life 2023, 13, 1324 9 of 13 tected in the liver parenchyma of patients with COVID-19 [73][74][75].…”
Section: Discussionmentioning
confidence: 99%
“…Hepatic biopsy pathology from a COVID-19 patient revealed that the SARS-CoV-2 virus could be seen in vessel lumens, endothelial cells of the portal vein, and the cytoplasm of hepatocytes, which leads to hepatocytic apoptosis (23,24). Cytokine storm and MIS secondary to SARS-CoV-2 infection could also result in immune-mediated hepatocellular damage, albumin synthesis suppression, and cholestasis (21, 25,26). Furthermore, hypoxia from acute respiratory and cardiac failure could also contribute to liver injury in critically ill patients (12,13).…”
Section: Discussionmentioning
confidence: 99%
“…By contrast, aberrant, nonresolving, and chronic inflammation are the leading contributors to multiple systemic diseases [ 4 , 5 ]. Notably, uncontrolled inflammation has been linked to the pathogenesis of many types of organ injuries, such as an acute lung injury attributed to sepsis, acute pancreatitis, burn injury, infections, and cigarette smoking exposure, as well as acute liver injury resulting from multiple etiologies, including sepsis, SARS-CoV-2 infection, and ischemia–reperfusion injury [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”
Section: Introductionmentioning
confidence: 99%