SARS-CoV-2 Is Present in Peritoneal Fluid in COVID-19 Patients

Coccolini, Federico; Tartaglia, Dario; Puglisi, Adolfo; Giordano, Cesira; Pistello, Mauro; Lodato, Marianna; Chiarugi, Massimo

doi:10.1097/sla.0000000000004030

Cited by 159 publications

(149 citation statements)

References 5 publications

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“…There are reports on the detection by qRT-PCR test of SARS-CoV-2 in different types of human specimens, such as bronchoalveolar, sputum, nasal and pharyngeal uids, feces, blood, urine, and, most recently, PF. The viral loads are different between these specimens, being higher in bronchioalveolar secretions (8,13,17). We present two cases of patients on PD with COVID-19 in whom the presence of viral RNA was found in the PF.…”

Section: Resultsmentioning

confidence: 90%

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Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

Ibarra-Hernandez

Alcantar-Vallín

Cabrera-Silva

et al. 2020

Preprint

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Background: Coronavirus disease-2019 (COVID-19) has a broad clinical presentation, involving multiple organs besides the respiratory system. Currently, there is little evidence available on the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in peritoneal fluid (PF). In this study, we describe the detection of SARS-CoV-2 in the PF of two patients with COVID 19 and kidney disease.Case presentation: Case 1: A 71-year-old woman with a history of end-stage kidney disease who presented with a 15-day evolution of progressive dyspnea, accompanied by dry cough and fever; IgM antibodies to SARS-CoV-2 were detected on admission. Real-time SARS-CoV-2 polymerase chain reaction (qRT-PCR) in the PF was positive. Three days after admission the patient's respiratory distress improved and she was discharged after 8 days of hospitalization.Case 2: A 78-year-old woman, with type 2 diabetes, hypertension, a 15-day history of polypnea, and a 5-day onset of fever and dyspnea. IgM and IgG antibodies to SARS-CoV-2 were detected on admission, as well as a positive nasopharyngeal qRT-PCR test for SARS-CoV-2. During hospitalization she developed acute kidney injury, requiring peritoneal dialysis, SARS-CoV-2 was confirmed in PF by qRT-PCRConclusions: These two cases highlights the importance of increasing the level of awareness for the presence and possible SARS-CoV-2 transmission through non-respiratory routes, like peritoneal fluid.Emphasis should be given to appropriate preventive strategies for minimizing the risk of transmission of COVID-19 from patients on peritoneal dialysis in both inpatient and outpatient settings.

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Section: Resultsmentioning

confidence: 90%

“…Currently, the presence of SARS-CoV-2 in PF remains controversial. Some reports have identi ed the presence of genetic material in the PF, and it was associated with PD failure (12,13). However, other reports have not detected the presence of the virus in the PF (14)(15)(16)(17).…”

Section: Read Full Licensementioning

confidence: 99%

Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

Ibarra-Hernandez

Alcantar-Vallín

Cabrera-Silva

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Studies show that patients infected with SARS-CoV-2 who underwent abdominal surgery have high postoperative morbidity and mortality, so surgery should be avoided or performed in the less invasive method [50]. "Primum non nocere" is a mainstay to most surgeons and something that most surgeons have lived by.…”

Section: Discussionmentioning

confidence: 99%

“…All precautions have been taken and none of the cases resulted in infection of the surgical team. Coccolino et al [50], on the contrary, communicated that the virus was present in the peritoneal liquid of a patient admitted with a diagnosis of intestinal mechanical obstruction due to small bowel volvulus associated to SARS-CoV-2 pneumonia, treated by open surgery and emphases on the importance of avoiding aerosols generating procedures in such patients (Table 3).…”

Section: Clinical Evidences Regarding Laparoscopy In Covid-19 Positivmentioning

confidence: 99%

Laparoscopic Surgery in COVID-19 Era—Safety and Ethical Issues

et al. 2020

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(1) Background:The paper aims to review the available evidence regarding the health risk of the aerosolization induced by laparoscopy induced and impact of the COVID-19 pandemic upon minimally invasive surgery.(2) Materials and methods: A systematic review of the literature was performed on PubMed, Medline and Scopus until July 10th. (3) Results: Chemicals, carcinogens and biologically active materials, such as bacteria and viruses, have been isolated in surgical smoke. However, the only evidence of viral transmission through surgical smoke to medical staff is post-laser ablation of HPV-positive genital warts. The reports of SARS-CoV-2 infected patients who underwent laparoscopic surgery revealed the presence of the virus, when tested, in digestive wall and stools in 50% of cases but not in bile or peritoneal fluid. All surgeries did not result in contamination of the personnel, when protective measures were applied, including personal protective equipment (PPE) and filtration of the pneumoperitoneum. There are no comparative studies between classical and laparoscopic surgery. (4) Conclusions: Previously published data showed there is a possible infectious and toxic risk related to surgical smoke but not particularly proven for SARS-CoV-2. Implementing standardized filtration systems for smoke evacuation during laparoscopy, although increases costs, is necessary to increase the safety and it will probably remain a routine also in the future.

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“…Esto nos permitió poder corregir el defecto abdominal sin llegar a presentar un síndrome compartimental por aumento de la presión intraabdominal al reintroducir las vísceras. Aunque siempre pensamos en la protección del paciente y en la patología, cabe mencionar la importancia que tiene la protección del personal quirúrgico y su toma de conciencia, especialmente en las cirugías de urgencia, dado que se ha demostrado que los niveles de carga viral en el los fluidos peritoneales es mayor que en el tracto respiratorio que, potencialmente, se aerosolizan al medioambiente 13 .…”

Section: Discussionunclassified

Coronavirus, COVID-19 and SARS-CoV-2

Megias¹

2020

Rev Hispanoam Hernia

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Se presenta un caso clínico de eventración infraumbilical complicada estrangulada con obstrucción intestinal que acude durante la pandemia de la COVID-19, causada por el virus SARS-CoV-2, al Hospital Municipal de la provincia de Buenos Aires (Argentina), con múltiples factores de riesgo y comorbilidades que potencialmente podían afectar a la evolución posoperatoria de la paciente. Se analiza, además de la técnica de plástica de pared abdominal, las medidas sanitarias implementadas para prevenir la infección del personal quirúrgico y del paciente.

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SARS-CoV-2 Is Present in Peritoneal Fluid in COVID-19 Patients

Cited by 159 publications

References 5 publications

Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

Laparoscopic Surgery in COVID-19 Era—Safety and Ethical Issues

Coronavirus, COVID-19 and SARS-CoV-2

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