SARS-CoV-2 infection reduces quality of sperm parameters: prospective one year follow-up study in 93 patients

Depuydt, Christophe; Bosmans, Eugène; Jonckheere, Jef; Donders, Francesca; Ombelet, Willem; Coppens, Astrid; Donders, Gilbert

doi:10.1016/j.ebiom.2023.104640

Cited by 8 publications

(2 citation statements)

References 32 publications

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“…This provides conclusive evidence for the impact of COVID-19 on sperm cycle-dependent parameters, with a possible mechanism involving temporary suppression of sperm production due to SARS-CoV-2 infection, specifically through the temporal immune-mediated arrest of active meiosis. However, this mechanism is temporary [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily

Zhang,

Wang

et al. 2024

Virol J

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Background The Corona Virus Disease 2019 (COVID-19) pandemic has raised concerns regarding its potential impact on male reproductive health. However, the impact of COVID-19 on sperm quality remains uncertain. This retrospective study aimed to investigate the short-term and relatively long-term effects of COVID-19 infection on sperm quality. Methods A total of 85 males with fertility requirements, who underwent semen evaluation at Guilin People’s Hospital between June 2022 and July 2023, were included in the study. Changes in semen parameters were analyzed across three specific timeframes: within 6 months before COVID-19 infection, within 3 months after COVID-19 infection, and 3–6 months after COVID-19 recovery. Results The results revealed that the sperm concentration and total sperm number were significantly lower after infection compared to before, while in the recovery period, the sperm concentration, total sperm count, progressive motility, and normal morphology significantly increased. Comparing the three periods, the most significant difference was observed in sperm concentration, which exhibited a significant decrease after infection but returned to normal levels after recovery from COVID-19. Conclusions These findings suggest that COVID-19 may exert some impact on sperm quality, particularly evidenced by decreased sperm concentration post-infection. Fortunately, these effects on semen parameters appear to be temporary, with gradual restoration of semen parameters within 3–6 months after recovery. However, further research is needed to explore the underlying mechanisms and long-term implications of these observed changes in semen parameters.

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Section: Discussionmentioning

confidence: 99%

Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily

Zhang,

Wang

et al. 2024

Virol J

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“…Early studies have established that SARS-CoV-2 can impact on male reproductive system. Some scientific evidence has shown that COVID-19 infection can adversely affect testes and sperm quality ( 7 - 9 ), but other studies suggest that SARS-CoV-2 genetic material was rarely found in semen samples, with no observed viral transmission during sexual contact or assisted reproductive techniques ( 10 - 12 ). Recent bioinformatics evidence shows that the testis is a suspected target organ for SARS-CoV-2, and it is potentially vulnerable towards SARS-CoV-2 infection.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 vaccination and semen quality: a study based on sperm donor candidate data in southwest China

Yang,

Tang,

Zhan

et al. 2024

Transl Androl Urol

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Background The coronavirus disease 2019 (COVID-19) pandemic has been a global health crisis and continues to pose risk to population health at the present. Vaccination against this disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has become a public health priority worldwide. Yet, limited information is available on the potential impact of such vaccines on human fertility. Methods To examine the relationship between COVID-19 vaccination and male fertility, we conducted an observational study on sperm donor candidates in China who received Chinese COVID-19 vaccines between January 1, 2020 to December 31, 2021. Results A total of 2,955 semen samples from 564 individuals were assessed along with vaccination information. Statistical analyses were conducted on both the entire study population and the subgroup of individuals who provided repeated semen samples before and after vaccination. While motility related parameters [progressive rate, curvilinear velocity (VCL), average path velocity (VAP), straight-line velocity (VSL), wobble (WOB), straightness (STR), linearity (LIN), amplitude of lateral head displacement (ALH), beat-cross frequency (BCF)] exhibited statistically significant difference before and after vaccination based on Welch two-sample test, mixed effects regression results based on repeated measures from the same individuals indicated that vaccination was not statistically associated with sperm quality parameters except for VCL, VAP, and VSL. Individual variability was the key determinant of sperm quality variance, with contribution ranging from 19% to 82%. Conclusions Findings from our study could help to enhance current understanding of male reproductive health in the context of the global pandemic.

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Zinc as a Possible Critical Element to Prevent Harmful Effects of COVID-19 on Testicular Function: a Narrative Review

Chemek,

Kadi,

AL-Mahdawi

et al. 2024

Reprod. Sci.

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SARS-CoV-2 infection reduces quality of sperm parameters: prospective one year follow-up study in 93 patients

Cited by 8 publications

References 32 publications

Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily

Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily

SARS-CoV-2 vaccination and semen quality: a study based on sperm donor candidate data in southwest China

Zinc as a Possible Critical Element to Prevent Harmful Effects of COVID-19 on Testicular Function: a Narrative Review

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