SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis

Seth, Gaurav; Sethi, Saira; Bhattarai, Shristi; Saini, Geetanjali; Singh, C. B.; Aneja, Ritu

doi:10.3390/cancers12113266

Cited by 25 publications

(29 citation statements)

References 88 publications

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“…The finding that 24% and 39% of patients hospitalised with COVID-19 require follow-up care contrasts with estimates for all individuals diagnosed COVID-19 with COVID-19 from the UK (10%) 26 and the US (35%). 27 The findings also provide support for claims that older adults 3 and individuals with pre-existing health conditions 9 – 13 are more likely to experience ongoing COVID-19 complications requiring follow-up. Moreover, it was notable that this study’s GP attendees had higher readmission rates than those observed among the general population in previous studies.…”

Section: Discussionsupporting

confidence: 61%

“…Immunocompromised populations (for example, people receiving cancer therapies such as chemotherapy, radiotherapy, and immunotherapy; and individuals with HIV) appear more likely to contract COVID-19. 8 , 9 Comorbidities such as hypertension, diabetes mellitus, cardiovascular diseases, and chronic obstructive pulmonary diseases are also common among those with COVID-19. 10 To compound matters, individuals with pre-existing health conditions are often more susceptible to severe COVID-19-related illness and injury.…”

Section: Introductionmentioning

confidence: 99%

“… 10 To compound matters, individuals with pre-existing health conditions are often more susceptible to severe COVID-19-related illness and injury. At-risk populations include those with weaker immune systems (for example, recipients of immunosuppressant therapy and populations with HIV), 8 , 9 and those with chronic health conditions such as hypertension, 10 , 11 diabetes, 10 , 11 cardiac illnesses, 4 , 10 – 12 chronic lung disease, 13 liver disease, 14 haematological malignancy, 15 chronic kidney disease, 16 and neurological conditions including dementia, Parkinson’s, epilepsy, multiple sclerosis, and spinal cord injury. 16 Evidence regarding COVID-19-related health impacts for groups — including pregnant patients and their babies, 17 patients who are immunocompromised, patients with diabetes, 9 , 18 and patients with asthma 19 — is mixed in terms of clinical outcomes and evidence availability.…”

Section: Introductionmentioning

confidence: 99%

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General practice attendances among patients attending a post-COVID-19 clinic: a pilot study

et al. 2021

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BackgroundAbout 10-35% of people with COVID-19 merit medical care within three weeks of infection. However, the prevalence of ongoing care needs among those experiencing severe COVID-19 illness is unclear.AimThis pilot study aimed to address this knowledge gap by examining GP attendance trends among patients attending a post-COVID-19 hospital follow-up clinic, 3-6 months after an initial clinic visit.Design, and SettingData was collected from adult patients attending a post-COVID-19 follow-up clinic at the Mater Misericordiae University Hospital, Dublin, Ireland.MethodParticipants completed questionnaires outlining their demographics, medical histories, emergency hospital admissions/re-admissions where applicable, and where relevant, GP attendances following hospital discharge. Analyses were conducted using descriptive/inferential statistics.ResultsParticipants’ (n=153) median age =43.5 (IQR =30.9–52.1 years). There were 105 females (68.6%, 95% CI=61.3%–75.9%). Various medical histories were reported among participants. 67 (43.2%, 95% CI=35.9%–51.6%) received emergency COVID-19 hospital care. Older adults, males, ICU admissions, and re-admissions were common among hospital attendees. Of the hospital attendees, 16 (24%, 95% CI=13.7%–34.2%) and 26 (39%, 95% CI=27.3%–50.7%) attended GPs within seven and 30 days of hospital discharge. Older adults, people with pre-existing medical conditions, and individuals admitted to ICU/readmitted to hospital were common among general practice attendees.ConclusionPersistent health issues appear to be common among severe COVID-19 patients, particularly those who are older adults, have pre-existing health problems, and had been in ICU and/or re-admission care. Larger scale studies of ongoing COVID-19 care needs in general practice/primary care are required.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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General practice attendances among patients attending a post-COVID-19 clinic: a pilot study

et al. 2021

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“…SARS-CoV-2 diagnosis in cancer patients is crucial for the prevention of the spread of the virus and the potential negative affect of the antineoplastic therapy on its course. Symptoms of COVID-19 in patients with malignancies very often are mild or absent, but cancer patients' mortality from complications of COVID-19 is more than twice as high as in the general population (5.6% vs. 2.3%, respectively) (20). The absence of specific clinical manifestations of COVID-19 in both general population and patients with malignant tumors in particular, create difficulties in infection detection.…”

Section: Coronavirus Diagnosis In Cancer Patientsmentioning

confidence: 99%

Special aspects of medical care for cancer patients during COVID-19 pandemic

et al. 2022

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The biggest challenge for the World Health Organization today is the fight against the COVID-19 pandemic. The current situation prompted major adjustments in the system of cancer care. In this review, we investigate the aspects of cancer treatment and care during the pandemic, since in this setting oncological services face challenges in determining the feasibility of anticancer treatments while minimizing the risk of infection. Cancer patients are at a higher risk from COVID-19 disease. Therefore, oncological community is discussing on the priorities for providing cancer therapies and care and at the same time minimizing the risk of infection.

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“…haematological cancers, as well as treatment-related immunosuppression, thus increasing risk of infection). [30] Patients with cancer have also been reported to be at increased risk of COVID-19 severity, including hospitalisation and death. [6][7][8][9] We found that cancer was associated with a higher risk of direct hospitalisation with COVID-19, regardless of years since cancer diagnosis; whereas only 1-5-year cancer patients had a higher risk of subsequent hospitalisation (following an outpatient diagnosis).…”

mentioning

confidence: 99%

Cancer and the risk of COVID-19 diagnosis, hospitalisation, and death: a population-based multi-state cohort study including 4,618,377 adults in Catalonia, Spain

Roel

Pistillo

Recalde

et al. 2021

Preprint

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Objectives: To investigate the associations between cancer and risk of outpatient COVID-19 diagnosis, hospitalisation, and COVID-19-related death, overall and by years since cancer diagnosis (<1-year, 1-5-years, >5-years), sex, age, and cancer type. Design: Population-based cohort study Setting: Primary care electronic health records including ~80% of the population in Catalonia, Spain, linked to hospital and mortality records between 1 March and 6 May 2020. Participants: Individuals aged ≥18 years with at least one year of prior medical history available from the general population. Cancer was defined as any prior diagnosis of a primary invasive malignancy excluding non-melanoma skin cancer. Main outcome measures: Cause-specific hazard ratios (aHR) with 95% confidence intervals for each outcome. Estimates were adjusted by age, sex, deprivation, smoking status, and comorbidities. Results: We included 4,618,377 adults, of which 260,667 (5.6%) had a history of cancer. Patients with cancer were older and had more comorbidities than cancer-free patients. A total of 98,951 individuals (5.5% with cancer) were diagnosed and 6,355 (16.4% with cancer) were directly hospitalised (no prior diagnosis) with COVID-19. Of those diagnosed, 6,851 were subsequently hospitalised (10.7% with cancer) and 3,227 died without being hospitalised (18.5% with cancer). Among those hospitalised, 1,963 (22.5% with cancer) died. Cancer was associated with an increased risk of COVID-19 diagnosis (aHR: 1.08; 95% confidence interval [1.05-1.11]); direct COVID-19 hospitalisation (1.33 [1.24-1.43]); and death following a COVID-19 hospitalisation (1.12 [1.01-1.25]). These associations were stronger for patients recently diagnosed with cancer, aged <70 years, and with haematological cancers. Conclusions: Patients recently diagnosed with cancer, aged <70 years, or with haematological cancers are a high-risk population for COVID-19 diagnosis and severity. These patients should be prioritised in COVID-19 vaccination campaigns and continued non-pharmaceutical interventions.

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SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis

Cited by 25 publications

References 88 publications

General practice attendances among patients attending a post-COVID-19 clinic: a pilot study

General practice attendances among patients attending a post-COVID-19 clinic: a pilot study

Special aspects of medical care for cancer patients during COVID-19 pandemic

Cancer and the risk of COVID-19 diagnosis, hospitalisation, and death: a population-based multi-state cohort study including 4,618,377 adults in Catalonia, Spain

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