SARS-CoV-2 Infection and Outcomes in Children with Inflammatory Bowel Diseases: A Systematic Review

Batsiou, Anastasia; Mantzios, Petros G.; Piovani, Daniele; Tsantes, Andreas G.; Taliaka, Paschalia Kopanou; Liakou, Paraskevi; Iacovidou, Nicoletta; Tsantes, Argirios Ε.; Bonovas, Stefanos; Sokou, Rozeta

doi:10.3390/jcm11237238

Cited by 4 publications

(4 citation statements)

References 55 publications

(116 reference statements)

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“…In a recent systematic review of 4006 children with IBD, 390 (9.7%) tested positive for SARS-CoV-2. Out of the 339 patients in whom the clinical course was reported, only 20 (5.9%) were hospitalized and two (0.6%) required admission to the ICU, with no deaths reported [22]. These findings support previous observations that outcomes in children with IBD and COVID-19 are similar to those in healthy children.…”

Section: Covid-19 In Patients With Inflammatory Bowel Diseasesupporting

confidence: 84%

COVID-19 and the gastrointestinal tract in children

Riera-Canales,

Llanos-Chea

2023

Current Opinion in Pediatrics

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Purpose of reviewThis is an overview of the effects of COVID-19 in the gastrointestinal tract in children, and current evidence of the impact of COVID-19 in pediatric patients with chronic gastrointestinal conditions, including inflammatory bowel disease (IBD), chronic liver disease, and disorders of the gut-brain interaction. Recent findingsChildren with COVID-19 have a milder course and more favorable outcomes than adults, even in those with immunosuppression due to IBD or liver transplantation. Children with chronic gastrointestinal conditions do not have worse clinical outcomes than healthy children and infection itself has not been linked to an increased incidence of conditions such as IBD and celiac disease, but results regarding postinfectious irritable bowel syndrome are mixed.

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Section: Covid-19 In Patients With Inflammatory Bowel Diseasesupporting

confidence: 84%

COVID-19 and the gastrointestinal tract in children

Riera-Canales,

Llanos-Chea

2023

Current Opinion in Pediatrics

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“…The exact reason for the association between certain underlying diseases and COVID-19 severity among older individuals was not clear, which should be explored in the future. Similarly, Batsiou, A. et al reviewed SARS-CoV-2 infection and outcomes in children with inflammatory bowel disease (IBD) and showed that IBD patients with SARS-CoV-2 infection did not have a more severe clinical course or disease progression [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis on the Association between Peptic Ulcer Disease and COVID-19 Severity

Wang

Shi

et al. 2023

Vaccines

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The association between peptic ulcer disease and the severity of coronavirus disease 2019 (COVID-19) is inconclusive across individual studies. Thus, this study aimed to investigate whether there was a significant association between peptic ulcer disease and COVID-19 severity through a meta-analysis. The electronic databases (Web of Science, Wiley, Springer, EMBASE, Elsevier, Cochrane Library, Scopus and PubMed) were retrieved for all eligible studies. The Stata 11.2 software was used for all statistical analyses. The pooled odds ratio (OR) with a 95% confidence interval (CI) was calculated by a random-effects meta-analysis model. The heterogeneity was evaluated by the inconsistency index (I2) and Cochran’s Q test. Egger’s analysis and Begg’s analysis were conducted to evaluate the publication bias. Meta-regression analysis and subgroup analysis were done to explore the potential source of heterogeneity. Totally, our findings based on confounding variables-adjusted data indicated that there was no significant association between peptic ulcer disease and the higher risk for COVID-19 severity (pooled OR = 1.17, 95% CI: 0.97–1.41) based on 15 eligible studies with 4,533,426 participants. When the subgroup analysis was performed by age (mean or median), there was a significant association between peptic ulcer disease and a higher risk for COVID-19 severity among studies with age ≥ 60 years old (pooled OR = 1.15, 95% CI: 1.01–1.32), but not among studies with age < 60 years old (pooled OR = 1.16, 95% CI: 0.89–1.50). Our meta-analysis showed that there was a significant association between peptic ulcer disease and a higher risk for COVID-19 severity among older patients but not among younger patients.

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“…Kinder und Jugendliche mit CED haben wie gesunde Kinder ein geringes Risiko für einen schweren Verlauf einer SARS-CoV-2 Infektion im Vergleich zu Erwachsenen. In einem systematischen Review von 14 Studien mit insgesamt 4006 pädiatrischen CED-Patienten wurden von 390 Patienten (9,7 %) mit nachgewiesener Infektion nur 5,9 % hospitalisiert und 0,6 % benötigten eine Behandlung auf eine Intensivstation; Todesfälle traten nicht auf [33].…”

Section: Leitlinieunclassified