SARS-CoV-2 Infection and Lung Regeneration

Zhao, Fuxiaonan; Ma, Qingwen; Yue, Qing; Chen, Huaiyong

doi:10.1128/cmr.00188-21

Cited by 28 publications

(23 citation statements)

References 264 publications

(245 reference statements)

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“…After initial damage, with the acute phase manifesting as respiratory symptoms [ 7 ], an evolving multisystem inflammatory reaction is responsible for the multisystem inflammatory syndrome (MIS) seen in children (MIS-C) and adults (MIS-A), and in survivors with persistent symptoms.…”

Section: Introductionmentioning

confidence: 99%

The Multifaceted Manifestations of Multisystem Inflammatory Syndrome during the SARS-CoV-2 Pandemic

et al. 2022

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The novel coronavirus SARS-CoV-2, which has similarities to the 2002–2003 severe acute respiratory syndrome coronavirus known as SARS-CoV-1, causes the infectious disease designated COVID-19 by the World Health Organization (Coronavirus Disease 2019). Although the first reports indicated that activity of the virus is centered in the lungs, it was soon acknowledged that SARS-CoV-2 causes a multisystem disease. Indeed, this new pathogen causes a variety of syndromes, including asymptomatic disease; mild disease; moderate disease; a severe form that requires hospitalization, intensive care, and mechanical ventilation; multisystem inflammatory disease; and a condition called long COVID or postacute sequelae of SARS-CoV-2 infection. Some of these syndromes resemble previously described disorders, including those with no confirmed etiology, such as Kawasaki disease. After recognition of a distinct multisystem inflammatory syndrome in children, followed by a similar syndrome in adults, various multisystem syndromes occurring during the pandemic associated or related to SARS-CoV-2 began to be identified. A typical pattern of cytokine and chemokine dysregulation occurs in these complex syndromes; however, the disorders have distinct immunological determinants that may help to differentiate them. This review discusses the origins of the different trajectories of the inflammatory syndromes related to SARS-CoV-2 infection.

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Section: Introductionmentioning

confidence: 99%

The Multifaceted Manifestations of Multisystem Inflammatory Syndrome during the SARS-CoV-2 Pandemic

et al. 2022

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“…Complex lung regeneration and repair programs exist to replenish damaged cell populations. In addition to clinical treatments being applied, it is necessary to promote lung regeneration for COVID-19 patients (Zhao et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration

Shi

Li²,

Yuan³

et al. 2023

Front. Bioeng. Biotechnol.

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Objectives An acute injury is often accompanied by tissue regeneration. In this process, epithelial cells show a tendency of cell proliferation under the induction of injury stress, inflammatory factors, and other factors, accompanied by a temporary decline of cellular function. Regulating this regenerative process and avoiding chronic injury is a concern of regenerative medicine. The severe coronavirus disease 2019 (COVID-19) has posed a significant threat to people’s health caused by the coronavirus. Acute liver failure (ALF) is a clinical syndrome resulting from rapid liver dysfunction with a fatal outcome. We hope to analyze the two diseases together to find a way for acute failure treatment.Methods COVID-19 dataset (GSE180226) and ALF dataset (GSE38941) were downloaded from the Gene Expression Omnibus (GEO) database, and the “Deseq2” package and “limma” package were used to identify differentially expressed genes (DEGs). Common DEGs were used for hub genes exploration, Protein-Protein Interaction (PPI) network construction, Gene Ontology (GO) functional enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) was used to verify the role of hub genes in liver regeneration during in vitro expansion of liver cells and a CCl4-induced ALF mice model.Results: The common gene analysis of the COVID-19 and ALF databases revealed 15 hub genes from 418 common DEGs. These hub genes, including CDC20, were related to cell proliferation and mitosis regulation, reflecting the consistent tissue regeneration change after the injury. Furthermore, hub genes were verified in vitro expansion of liver cells and in vivo ALF model. On this basis, the potential therapeutic small molecule of ALF was found by targeting the hub gene CDC20.Conclusion We have identified hub genes for epithelial cell regeneration under acute injury conditions and explored a new small molecule Apcin for liver function maintenance and ALF treatment. These findings may provide new approaches and ideas for treating COVID-19 patients with ALF.

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“…[6] The most vulnerable cells are located on the surface of the alveoli. [7] Damage to AT1 stimulates the rapid proliferation and differentiation of AT2 cells, which also regenerates the tissue barrier function. [5] Alveolar regeneration after acute lung injury has been observed in animal studies demonstrating the key function of AT2 cells.…”

Section: Discussionmentioning

confidence: 99%

Full recovery of lung tissue after severe viral pneumonia H1N1: A case report with 10 years follow-up

Kočan¹,

Firment

Pirníková

et al. 2023

Medicine

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Rationale: World healthcare frequently faced severe viral pneumonia cases in the last decades, due to pandemic situations such as H1N1, MERS-CoV, and SARS-COVID-19. Patient concerns: The impact of viral infection on lung structure, lung function, and overall mortality was significant. The quality of life and assumed life expectancy was decreased with the supposed development of lung fibrosis in involved survived patients. Diagnoses: We described the course and treatment of severe pneumonia H1N1 in a 30-year-old patient. Interventions: Patient was included in a study regarding the therapeutic efficacy of selenium ClinicalTrials.gov ID: NCT02026856 with 10 years follow-up with concurrently documented X-ray lung examinations and final histology of lung tissue after sudden death. Outcomes: All sequential examinations and histological findings show a healing trend with the final full recovery of lung tissue.

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SARS-CoV-2 Infection and Lung Regeneration

Cited by 28 publications

References 264 publications

The Multifaceted Manifestations of Multisystem Inflammatory Syndrome during the SARS-CoV-2 Pandemic

The Multifaceted Manifestations of Multisystem Inflammatory Syndrome during the SARS-CoV-2 Pandemic

Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration

Full recovery of lung tissue after severe viral pneumonia H1N1: A case report with 10 years follow-up

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