SARS-CoV-2 infection and COVID-19 and human reproduction – A changing perspective – A 2022 update

Delamuta, Luciana C.; Monteleone, Pedro Augusto Araújo; Filho, Edson Santos Ferreira; Heinrich-Oliveira, Vanessa; Soares-Júnior, José Maria; Baracat, Edmund C.; Maciel, Gustavo Arantes Rosa

doi:10.1016/j.clinsp.2023.100166

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…However, in frozen embryo transfer (FET) cycles of patients with previous SARS-CoV-2 infection, in which oocytes were retrieved prior to infection, decreased pregnancy rates were observed, particularly in patients who recovered less than 60 days prior to embryo transfer 19 . On the other hand, females who underwent IVF/ICSI cycles and had a history of asymptomatic or mild SARS-CoV-2 infection showed similar outcomes in terms of embryo laboratory and IVF outcomes 9,17,30 . Nonetheless, inconclusive evidence suggests the need for further studies with large sample sizes.…”

Section: Discussionmentioning

confidence: 97%

The Impact of Post Embryo Transfer SARS-CoV-2 Infection on Pregnancy in In Vitro Fertilization: A Prospective Cohort Study

Li¹,

Yao

Chen

et al. 2023

Preprint

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Importance: Limited knowledge exists on the effects of SARS-CoV-2 infection after embryo transfer, despite an increasing number of studies exploring the impact of previous SARS-CoV-2 infection on IVF outcomes. Objective: This prospective cohort study aimed to assess the influence of SARS-CoV-2 infection at various time stages after embryo transfer on pregnancy outcomes in patients undergoing conventional in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI) treatment. Design: The study was conducted at a single public IVF center in China. Setting This was a population-based prospective cohort study. Participants: Female patients aged 20 to 39 years, with a body mass index (BMI) between 18 and 30 kg/m2, undergoing IVF/ICSI treatment, were enrolled from September 2022 to December 2022, with follow-up until March 2023. Exposure: The pregnancy outcome of patients was compared between those SARS-CoV-2-infected after embryo transfer and those noninfected during the follow-up period. Main Outcomes and Measures: The pregnancy outcomes included biochemical pregnancy rate, implantation rate, clinical pregnancy rate, and early miscarriage rate. Results: A total of 857 female patients undergoing IVF/ICSI treatment were included in the analysis. We observed the incidence of SARS-CoV-2 infection within 10 weeks after embryo transfer. The biochemical pregnancy rate and implantation rate were lower in the infected group than the uninfected group (58.1% vs 65.9%; 36.6% vs 44.0%, respectively), but no statistically significant. Although, the clinical pregnancy rate was significant lower in the infection group when compared with the uninfected group (49.1%vs 58.2%, p < 0.05), after adjustment for confounders, this increased risk was no longer significant between the two groups (adjusted OR, 0.736, 95% CI, 0.518-1.046). With continued follow-up, a slightly higher risk of early miscarriage in the infected group compared to the uninfected group (9.3% vs 8.8%), but it was not significant (adjusted OR, 0.907, 95% CI, 0.414-1.986). Conclusions and Relevance: The study's findings suggested that SARS-CoV-2 infection within 10 weeks after embryo transfer may have not significantly affect pregnancy outcomes. This evidence allays concerns and provides valuable insights for assisted reproduction practices.

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Section: Discussionmentioning

confidence: 97%

The Impact of Post Embryo Transfer SARS-CoV-2 Infection on Pregnancy in In Vitro Fertilization: A Prospective Cohort Study

Li¹,

Yao

Chen

et al. 2023

Preprint

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“…In a systematic review and meta‐analysis study by Zaçe et al researchers reviewed effect of COVID‐19 vaccination (Gam‐COVID‐Vac and BNT162b2) on different outcomes such as sperm characteristics, steroid hormones levels, biochemical and clinical pregnancy rate; no significant finding was reported and authors concluded that COVID‐19 vaccinations is not associated with impaired fertility outcomes 5 . Vaccination with mRNA vaccines also showed no change in gametes and embryo parameters 43 . Hasdemir et al study was the only one reporting a significant decrease in level of AMH among vaccinated patients, they compared AMH level among healthcare workers pre and post vaccination.…”

Section: Discussionmentioning

confidence: 99%

“… 5 Vaccination with mRNA vaccines also showed no change in gametes and embryo parameters. 43 Hasdemir et al study was the only one reporting a significant decrease in level of AMH among vaccinated patients, they compared AMH level among healthcare workers pre and post vaccination. They measured AMH levels several time post vaccinations and AMH levels were only measured once before vaccination.…”

Section: Discussionmentioning

confidence: 99%

The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis

Ghaemi,

Hantoushzadeh,

Shafiee

et al. 2024

Immunity Inflam & Disease

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ObjectiveThe current study aims to evaluate the impact of COVID‐19 infection and vaccination on ovarian reserve by detecting the anti‐Mullerian hormone (AMH) level.MethodPubMed, Embase, Web of Science, and Scopus has been searched for studies assessing the effect of COVID‐19 infection and/or vaccination on AMH levels up to February 27, 2023. Based on PRISMA 2020 statement criteria, a systematic review and meta‐analysis of included studies were performed. The studies' quality was assessed by the National Institute of Health (NIH) quality assessment tool. The standardized mean difference (MD) of the AMH level was used and the quantitative values of each study were pooled separately by using a random effect model.ResultsOut of 246 studies screened, 18 were included in the systematic review and 14 in the meta‐analysis. Included studies were published between 2021 and 2022 and were conducted in different countries, including the USA (n = 3), China (n = 2), Russia (n = 2), Turkey (n = 5), Israel (n = 3), Czech (n = 2), and Spain (n = 1). Eight studies investigated the effect of SARS‐CoV‐2 infection on AMH levels, and ten studies investigated the possible effect of COVID‐19 vaccination on AMH levels. The pooled analysis showed a statistically significant decrease in AMH levels after COVID‐19 infection (SMD: −0.24; 95% CI: −0.36 to −0.11; I2 = 0%; p = .0003). Vaccination analysis showed a nonstatistically significant change in AMH levels after COVID‐19 vaccination (SMD: −0.11; 95% CI: −0.25 to 0.04; I2 = 35%; p = .14).ConclusionCOVID‐19 infection can result in ovarian reserve injury by reducing the AMH level but getting vaccinated against COVID‐19 has no impact on the AMH level.

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“…Viruses such as hepatitis B and C and HIV can affect the reproductive system and cause menstrual cycle disorders 7 . It is thought that COVID-19 specifically affects sex hormones and therefore causes changes in the menstrual cycle 8 , 9 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of menstrual cycle irregularities among young women based on coronavirus disease 2019 infection status: a cross-sectional study

Doğan,

Uncu,

Duman

2024

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The coronavirus disease 2019 pandemic that has emerged recently has significantly affected and continues to affect our lives. The Severe Acute Respiratory Syndrome Coronavirus 2 virus has significant effects on women’s health due to gender-related physiological differences. The aim of this study was to compare the menstrual cycle status of young women according to their status of having had coronavirus disease 2019. METHODS: This descriptive cross-sectional study was conducted with 220 young women aged between 18 and 25 years who received at least one dose of coronavirus disease 2019 vaccine. The study data were collected as a survey on the online platform. RESULTS: The descriptive characteristics of young women who had had and had not had coronavirus disease 2019 were distributed homogeneously between the groups (p>0.05). Furthermore, there was no statistical difference in terms of menstrual cycle patterns (p>0.05). The mean scores from the Premenstrual Syndrome Scale and its subscales and the mean scores from the COVID Stress Scale and its subscales were similar in both groups, and no statistically significant difference was identified (p>0.05). CONCLUSION: Although menstrual cycle irregularities due to coronavirus disease 2019 have been reported, these effects are usually observed during the pandemic. A decrease in stress and anxiety with the end of the pandemic may explain the return of the menstrual cycle to normal.

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SARS-CoV-2 infection and COVID-19 and human reproduction – A changing perspective – A 2022 update

Cited by 5 publications

References 20 publications

The Impact of Post Embryo Transfer SARS-CoV-2 Infection on Pregnancy in In Vitro Fertilization: A Prospective Cohort Study

The Impact of Post Embryo Transfer SARS-CoV-2 Infection on Pregnancy in In Vitro Fertilization: A Prospective Cohort Study

The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis

Comparison of menstrual cycle irregularities among young women based on coronavirus disease 2019 infection status: a cross-sectional study

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