SARS‐CoV‐2 induces blood‐brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

Qiao, Haowen; Deng, Xiangxue; Qiu, Lingxi; Qu, Yafei; Chiu, Yuanpu; Chen, Feixiang; Xia, Shangzhou; Muenzel, Cheyene; Ge, Tenghuan; Zhang, Zixin; Song, Pengfei; Bonnin, Alexandre; Zhao, Zhen; Yuan, Weiming

doi:10.1002/jmv.29671

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…35 Moreover, similarly to Sars-cov-2 virus though much rarer Sars-cov2-vaccinations could induce blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice, as well as changes in perivascular astrocytes, neurons and microglia, thus impairing the neurovascular unit. 36,37 Interestingly, pro-atherosclerotic risk factors and a history of previous ischemic strokes are common among patients without evidence of coagulopathy.…”

Section: Pathophysiology and Diagnosismentioning

confidence: 99%

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Neurovascular Adverse Effects of Sars-Cov-2 Vaccination

Panos,

Bargiotas,

Hadjigeorgiou

et al. 2024

DDDT

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The global deployment of SARS-CoV-2 vaccines has been pivotal in curbing the COVID-19 pandemic, reducing morbidity and mortality associated with the virus. While most of these vaccines have demonstrated high efficacy and overall safety, emerging reports have highlighted potential neurovascular adverse effects, albeit uncommon, associated with these vaccinations. This review aims to assess and summarize the current knowledge on the neurovascular complications arising post-SARS-CoV-2 vaccination. We conducted an extensive literature review, focusing on clinical studies and case reports to identify reported neurovascular events, such as ischemic stroke, cerebral sinus venous thrombosis, intracerebral hemorrhage, pituitary apoplexy and primary CNS angiitis Despite the relative rarity of these events, their impact on affected individuals underscores the importance of ongoing surveillance, early detection, and management strategies. We aim to provide healthcare professionals with the latest evidence on neurovascular adverse effects, facilitating informed decision-making in the context of SARS-CoV-2 vaccination programs. Furthermore, we highlight areas requiring further research to understand the pathophysiology of these adverse events better and to develop targeted prevention and treatment strategies.

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Section: Pathophysiology and Diagnosismentioning

confidence: 99%

“…Moreover, similarly to Sars-cov-2 virus though much rarer Sars-cov2-vaccinations could induce blood–brain barrier and choroid plexus barrier impairments and vascular inflammation in mice, as well as changes in perivascular astrocytes, neurons and microglia, thus impairing the neurovascular unit. 36 , 37 …”

Section: Ischemic Strokementioning

confidence: 99%

Neurovascular Adverse Effects of Sars-Cov-2 Vaccination

Panos,

Bargiotas,

Hadjigeorgiou

et al. 2024

DDDT

View full text Add to dashboard Cite

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Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection

Gáspár,

Szabó,

Ceglédi

et al. 2024

GeroScience

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The emergence of SARS-CoV-2 has precipitated a global pandemic with substantial long-term health implications, including the condition known as post-acute sequelae of SARS-CoV-2 infection (PASC), commonly referred to as Long COVID. PASC is marked by persistent symptoms such as fatigue, neurological issues, and autonomic dysfunction that persist for months beyond the acute phase of COVID-19. This review examines the potential role of herpesvirus reactivation, specifically Epstein-Barr virus (EBV) and cytomegalovirus (CMV), in the pathogenesis of PASC. Elevated antibody titers and specific T cell responses suggest recent herpesvirus reactivation in some PASC patients, although viremia is not consistently detected. SARS-CoV-2 exhibits endothelial trophism, directly affecting the vascular endothelium and contributing to microvascular pathologies. These pathologies are significant in PASC, where microvascular dysfunction may underlie various chronic symptoms. Similarly, herpesviruses like CMV also exhibit endothelial trophism, which may exacerbate endothelial damage when reactivated. Evidence suggests that EBV and CMV reactivation could indirectly contribute to the immune dysregulation, immunosenescence, and autoimmune responses observed in PASC. Additionally, EBV may play a role in the genesis of neurological symptoms through creating mitochondrial dysfunction, though direct confirmation remains elusive. The reviewed evidence suggests that while herpesviruses may not play a direct role in the pathogenesis of PASC, their potential indirect effects, especially in the context of endothelial involvement, warrant further investigation.

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Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study

Wang,

Yang,

Zheng

et al. 2024

J Cereb Blood Flow Metab

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Neuroimaging studies have indicated that altered cerebral blood flow (CBF) was associated with the long-term symptoms of postacute sequelae of SARS-CoV-2 infection (PASC), also known as “long COVID”. COVID-19 and long COVID were found to be strongly associated with host gene expression. Nevertheless, the relationships between altered CBF, clinical symptoms, and gene expression in the central nervous system (CNS) remain unclear in individuals with long COVID. This study aimed to explore the genetic mechanisms of CBF abnormalities in individuals with long COVID by transcriptomic-neuroimaging spatial association. Lower CBF in the left frontal-temporal gyrus was associated with higher fatigue and worse cognition in individuals with long COVID. This CBF pattern was spatially associated with the expression of 2,178 genes, which were enriched in the molecular functions and biological pathways of COVID-19. Our study suggested that lower CBF is associated with persistent clinical symptoms in long COVID individuals, possibly as a consequence of the complex interactions among multiple COVID-19-related genes, which contributes to our understanding of the impact of adverse CNS outcomes and the trajectory of development to long COVID.

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SARS‐CoV‐2 induces blood‐brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

Cited by 3 publications

References 49 publications

Neurovascular Adverse Effects of Sars-Cov-2 Vaccination

Neurovascular Adverse Effects of Sars-Cov-2 Vaccination

Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection

Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study

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