SARS-CoV-2 induced changes in the glycosylation pattern in the respiratory tract of Golden Syrian hamsters

Barlang, Lea-Adriana; Mohl, Björn-Patrick; Blaurock, Claudia; Harder, Sophia; Breithaupt, Angele; Merkel, Olivia M.; Balkema-Buschmann, Anne; Popp, Andreas

doi:10.1016/j.acthis.2023.152077

Cited by 2 publications

(2 citation statements)

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“…The data allowed us to identify apoptosis as a consequence of virus-host interactions. It is likely that the development of apoptosis has a significant influence on the virus-host interaction in the course of a new coronavirus infection [19], as it is one of the leading mechanisms of cell destruction in COVID-19-related deaths in children.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the majority of suggestions concerning the pathogenesis of COVID-19 in children are directly connected to the absence of concrete facts about the pathological morphology of the disease. The assessment of virus-host interactions is greatly important in terms of understanding the infection's course and development [19]. It is necessary to note that the investigation of COVID-19 pathogenesis is also the basis for understanding another topical problem: the development of post-COVID conditions.…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 in Children: Molecular Profile and Pathological Features

Nasyrov,

Ivanov,

Krasnogorskaya

et al. 2023

IJMS

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Although the World Health Organization has declared the end of the COVID-19 pandemic, doctors continue to register new cases of the disease among both adults and children. Unfortunately, the course of COVID-19 in children can have a severe form, with death being a potential outcome. The absence of published works discussing the pathological morphology of COVID-19 in children prevents the objective analysis of the disease’s pathogenesis, including among the adult population. In this vein, the objective of our study is to identify the morphological features of the lungs’ involvement and evaluate virus–host interactions in the case of COVID-19 in patients at a pediatric medical practice. We present the results of the study of the lungs of three children who died due to COVID-19, highlighting the predominant involvement of their respiratory organs at different stages of the disease (5, 21, and 50 days). This article presents data obtained from histopathological and immunohistochemical investigations, taking into account the results of clinical and laboratory indicators and intravital and postmortem SARS-CoV-2 PCR investigations. The common finding of all of the examined COVID-19 cases is the involvement of the endothelium in microcirculation vessels, which are considered to be a primary target of various pathogenic influencing factors. We also discuss both the significance of apoptosis as a result of virus–host interactions and the most likely cause of endothelium cell destruction. The results of this study could be useful for the development of endothelium-protective therapy to prevent the progression of disseminated intravascular coagulation syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%