SARS-CoV-2: fear versus data

Roussel, Yanis; Giraud-Gatineau, Audrey; Jimeno, Marie-Thérèse; Rolain, Jean‐Marc; Zandotti, Christine; Colson, Philippe; Raoult, Didier

doi:10.1016/j.ijantimicag.2020.105947

Cited by 78 publications

(69 citation statements)

References 26 publications

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“…Vaccination past the peak of infections and long-term school closures late in the outbreak appear less cost-effective, underscoring the importance of timing. Roussel et al (2020) reported a mortality rate of 1.3% in OECD countries as of March 2, 2020. Onder al.…”

Section: Discussionmentioning

confidence: 99%

Evidence-Based, Cost-Effective Interventions To Suppress The COVID-19 Pandemic: A Systematic Review

Juneau

2020

Preprint

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Background: Countries vary in their response to the COVID-19 pandemic. Some emphasise social distancing, while others focus on other interventions. Evidence on the effectiveness and cost-effectiveness of these interventions is urgently needed to guide public health policy and avoid unnecessary damage to the economy and other harms. We aimed to provide a comprehensive summary of the evidence on epidemic control, with a focus on cost-effectiveness. were searched using a range of terms related to epidemic control. Reviews, randomized trials, observational studies, and modelling studies were included. Articles reporting on the effectiveness or cost-effectiveness of at least one intervention were included and grouped into higher-quality (randomized trials) and lower-quality evidence (other study designs). Findings:We found 1,653 papers; 34 were included. Higher-quality evidence was only available to support the effectiveness of hand washing and face masks. Modelling studies suggested that these measures are highly cost-effective. For other interventions, only evidence from observational and modelling studies was available. A cautious interpretation of this body of lower-quality evidence suggests that: (1) the most cost-effective interventions are swift contact tracing and case isolation, surveillance networks, protective equipment for healthcare workers, and early vaccination (when available); (2) home quarantines and stockpiling antivirals are less cost-All rights reserved. No reuse allowed without permission.

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Section: Discussionmentioning

confidence: 99%

Evidence-Based, Cost-Effective Interventions To Suppress The COVID-19 Pandemic: A Systematic Review

Juneau

2020

Preprint

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“…However, since asymptomatic carriers of SARS CoV-2 are highly infectious, the societal consequences of achieving herd immunity may be devastating [34]. Moreover, other coronaviruses may also stimulate population immunity in the pharynx of asymptomatic individuals that are not regularly systematically tested around the world [5].…”

Section: Surveillance Diagnosis and Treatment Of Covid-19 In Nigeriamentioning

confidence: 99%

“…The basis of managing COVID-19 with cocktails of drugs is because viral infections are ecosystem infections, where the outcomes depend on inoculums and surrounding microbiota, which is often bacterial [5]. This highlights why there is a need for antibiotic stewardship programs in Nigeria to help preserve the efficacy of commonly used antibiotics.…”

Section: Surveillance Diagnosis and Treatment Of Covid-19 In Nigeriamentioning

confidence: 99%

“…This disease emerged in late December 2019 in Wuhan, in Hubei province of China, and within three months, it had spread globally, prompting the World Health Organization (WHO) to declare COVID-19 a threat to world health [3,4]. SARS-CoV-2 belongs to the family Coronaviridae (of the order Nidovirales, large, positive single-stranded RNA viruses), which are important human and animal viruses, in permanent circulation with four members of this family causing respiratory infections (common cold) worldwide [5,6]. Although the SARS (in 2002) and Middle-East respiratory syndrome coronavirus (MERS-CoV) (in 2012) epidemics were not globally dispersed like COVID-19, they seem to have caused more fatalities than COVID-19 [5,7].…”

Section: Introductionmentioning

confidence: 99%

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A Perspective on Nigeria’s Preparedness, Response and Challenges to Mitigating the Spread of COVID-19

et al. 2020

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Coronavirus disease 2019 (COVID-19) is a novel disease pandemic that emerged in late 2019 in China, and later spread to other parts of the world, including Nigeria. This review analyzes the preparedness of Nigeria to the COVID-19 pandemic and recommends strategies that could be useful in controlling the disease. Published articles on COVID-19 worldwide, socioeconomic and disease status and preparedness to COVID-19 in Africa and Nigeria, were retrieved from databases such as Pubmed, MEDLINE, Scopus, Web of Knowledge and Google search engine. Nigeria is the most populous black nation in the world, and is one of the largest crude oil producers in the world. However, its healthcare system is dilapidated and weak, due to years of neglect and widespread corruption. As a result, Nigeria is vulnerable to COVID-19, as evidenced by the current geographical distribution of the disease in its population. Many socioeconomic factors could potentially facilitate the spread of COVID-19 in Nigeria. This could lead to a high caseload in the country, which could overwhelm the health care system. The application of social distancing, personal hygiene, especially hand hygiene and mask-wearing, as practiced in many countries, has proven to be effective to reduce the spread of COVID-19. In Nigeria, social distancing, in many instances, may be impracticable, given its large population, and a high density of people living in crowded conditions like slums and camps. Moreover, there is a sizeable population of internally displaced people, due to the attack by Boko Haram fighters in Northern Nigeria, and herdsmen in Southern Nigeria. The implementation of these measures is likely to be a great challenge. Nigeria has announced a complete lockdown for the containment of COVD-19, but its implementation and efficacy are doubtful, due to the same reasons previously mentioned.

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“…Limited understanding of the diverse range of tissues targeted by the virus and its potential receptors, there is an immediate need to understand SARS-CoV-2 entry mechanism and pathogenesis to develop effective therapeutics. It is recently identi ed that trimeric transmembrane spike glycoprotein of SARS-CoV-2 and SARS-CoV that share a high degree of similarity within the RBD, binds to the common human ACE-2 receptor, yet SARS-CoV-2 is highly infectious than SARS-CoV [22]. To investigate the difference in these highly similar spike proteins, we analyzed the phyletic relatedness of the spike proteins from coronaviruses that are known to infect humans.…”

Section: Molecular Docking and Simulationsmentioning

confidence: 99%

N-terminal domain (NTD) of SARS-CoV-2 spike-protein structurally resembles MERS-CoV NTD sialoside-binding pocket

Awasthi

Gulati²,

Sarkar

et al. 2020

Preprint

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COVID-19 novel coronavirus disease caused by SARS-CoV-2 causes severe lethal respiratory illness in humans and has recently developed into a worldwide pandemic. The lack of effective treatment strategy and vaccines against SARS-CoV-2 poses a threat to human health. Extremely high infection rate and multi-organ secondary infection within a short time period makes this virus more deadly and challenging for therapeutic interventions. Despite of high sequence similarity and utilization of common host-cell receptor, human angiotensin-converting enzyme-2 (ACE2) for virus entry, SARS-CoV-2 is much infectious than SARS-CoV. Structure-based sequence comparison of the N-terminal domain (NTD) of spike protein of MERS-CoV, SARS-CoV and SARS-CoV-2 illustrate three short stretches of amino acid motifs in SARS-CoV-2 , which appears to be the reminiscent of MERS-CoV sialoside binding pockets. These key differences with SARS-CoV and similarity with MERS-CoV, suggest an evolutionary adaptation of SARS-CoV-2 spike protein reciprocal interaction with host surface sialosides.

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SARS-CoV-2: fear versus data

Cited by 78 publications

References 26 publications

Evidence-Based, Cost-Effective Interventions To Suppress The COVID-19 Pandemic: A Systematic Review

Evidence-Based, Cost-Effective Interventions To Suppress The COVID-19 Pandemic: A Systematic Review

A Perspective on Nigeria’s Preparedness, Response and Challenges to Mitigating the Spread of COVID-19

N-terminal domain (NTD) of SARS-CoV-2 spike-protein structurally resembles MERS-CoV NTD sialoside-binding pocket

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