SARS-CoV-2 evolution and vaccines: cause for concern?

Williams, Thomas C; Burgers, Wendy A.

doi:10.1016/s2213-2600(21)00075-8

Cited by 173 publications

(164 citation statements)

References 18 publications

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“…Their track record brings hope that SARS-CoV-2 may soon be under control 13 as a consequence of a plethora of vaccine development efforts [14][15][16][17] . A potential cause of concern is the low rate of vaccine production and administration 18 coupled with reports of new strains with higher transmission rates 3,4,19 and even with potential for some degree of vaccine resistance 5,6,8,20 . A number of models considered the dynamics of the spread of a 1 vaccine-resistant strain in the population 9,10,21,22 .…”

Section: Mainmentioning

confidence: 99%

“…Vaccines are thought to be the best available solution for controlling the ongoing SARS-CoV-2 pandemic 1,2 . However, the emergence of vaccine-resistant strains [3][4][5][6] may come too rapidly for current vaccine developments to alleviate the health, economic and social consequences of the pandemic 7,8 . To quantify and characterize the risk of such a scenario, we created a SIR-derived model 9,10 with initial stochastic dynamics of the vaccine-resistant strain to study the probability of its emergence and establishment.…”

mentioning

confidence: 99%

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SARS-CoV-2 transmission, vaccination rate and the fate of resistant strains

Dermitzakis

et al. 2021

Preprint

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Vaccines are thought to be the best available solution for controlling the ongoing SARS-CoV-2 pandemic [1,2]. However, the emergence of vaccine-resistant strains [3-6] may come too rapidly for current vaccine developments to alleviate the health, economic and social consequences of the pandemic [7,8]. To quantify and characterize the risk of such a scenario, we created a SIR-derived model [9,10] with initial stochastic dynamics of the vaccine-resistant strain to study the probability of its emergence and establishment. Using parameters realistically resembling SARS-CoV-2 transmission, we model a wave-like pattern of the pandemic and consider the impact of the rate of vaccination and the strength of non-pharmaceutical intervention measures on the probability of emergence of a resistant strain. We found a counterintuitive result that the highest probability for the establishment of the resistant strain comes at a time of reduced non-pharmaceutical intervention measures when most individuals of the population have been vaccinated. Consequently, we show that a period of transmission reduction close to the end of the vaccination campaign can substantially reduce the probability of resistant strain establishment. Our results suggest that policymakers and individuals should consider maintaining non-pharmaceutical interventions [7,11,12] throughout the entire vaccination period.

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Section: Mainmentioning

confidence: 99%

mentioning

confidence: 99%

SARS-CoV-2 transmission, vaccination rate and the fate of resistant strains

Dermitzakis

et al. 2021

Preprint

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“…Studies have also provided insights into the genetic variants which could confer partial or complete resistance to antibodies (Weisblum et al, 2020) as well as panels of convalescent plasma. With vaccines being widely available, the evidence on the effect of genetic variants on efficacy of vaccines are also emerging (Williams and Burgers, 2021)…”

Section: Introductionmentioning

confidence: 99%

ESC - a comprehensive resource for SARS-CoV-2 immune escape variants

Rophina

Pandhare

Shamnath

et al. 2021

Preprint

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Ever since the breakout of COVID-19 disease, ceaseless genomic research to inspect the epidemiology and evolution of the pathogen has been undertaken globally. Large scale viral genome sequencing and analysis have uncovered the functional impact of numerous genetic variants in disease pathogenesis and transmission. Emerging evidence of mutations in spike protein domains escaping antibody neutralization is reported. We have a precise collation of manually curated variants in SARS-CoV-2 from literature with potential escape mechanisms from a range of neutralizing antibodies. This comprehensive repository encompasses a total of 532 variants accounting for 146 unique variants tested against 75 antibodies and patient convalescent plasma. This resource enables the user to gain access to an extensive annotation of SARS-CoV-2 escape mutations which we hope would contribute to exploring and understanding the underlying mechanisms of immune response against the pathogen. The resource is available at http://clingen.igib.res.in/esc/. Keywords : COVID-19, SARS-CoV-2, Neutralizing antibodies, Escape mutations, Genomes

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“…The coronavirus disease 2019 (COVID-19) has spread, infecting over 115 million people worldwide and approaching 2.6 million deaths globally by March 4, 2021. Despite the arrival of several candidate vaccines, which have effectively started to tackle the ongoing pandemic, several questions remain unanswered regarding the dynamics of COVID-19 infection and most importantly the continuing evolution and ever-changing mutational landscape of SARS-CoV-2 genomes [1]. In recent months, a sustained number of mutations of the viral genome have led to the emergence of "Variants of epidemiological concern".…”

Section: Introductionmentioning

confidence: 99%

Phylogenomic Evidence of Reinfection and Persistence of SARS-CoV-2: First Report from Colombia

et al. 2021

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The continuing evolution of SARS-CoV-2 and the emergence of novel variants have raised concerns about possible reinfection events and potential changes in the coronavirus disease 2019 (COVID-19) transmission dynamics. Utilizing Oxford Nanopore technologies, we sequenced paired samples of three patients with positive RT-PCR results in a 1–2-month window period, and subsequent phylogenetics and genetic polymorphism analysis of these genomes was performed. Herein, we report, for the first time, genomic evidence of one case of reinfection in Colombia, exhibiting different SARS-CoV-2 lineage classifications between samples (B.1 and B.1.1.269). Furthermore, we report two cases of possible viral persistence, highlighting the importance of deepening our understanding on the evolutionary intra-host traits of this virus throughout different timeframes of disease progression. These results emphasize the relevance of genomic surveillance as a tool for understanding SARS-CoV-2 infection dynamics, and how this may translate effectively to future control and mitigations efforts, such as the national vaccination program.

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SARS-CoV-2 evolution and vaccines: cause for concern?

Cited by 173 publications

References 18 publications

SARS-CoV-2 transmission, vaccination rate and the fate of resistant strains

SARS-CoV-2 transmission, vaccination rate and the fate of resistant strains

ESC - a comprehensive resource for SARS-CoV-2 immune escape variants

Phylogenomic Evidence of Reinfection and Persistence of SARS-CoV-2: First Report from Colombia

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