SARS-CoV-2:  Current Perspective on Control, Prevention, and Therapeutic Promise

Ikwuka, David Chibuike; Nwobodo, Ed; Anayehie, Bond; Eleje, George Uchenna; Ayuk, Adaeze C; Ogbuagu, Chukwuanugo Nkemakonam; Ugwu, Princewill

doi:10.18502/sjms.v15i5.7161

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…This study found that the COVID-19 hesitancy rate was 65.04%, and the strongest predictors related to vaccine acceptance were marital status, age, and Christian denominational affiliation. 32 Conversely, in this previous study in the nonhealth worker population, gender, occupation, previous vaccination experience, awareness of COVID-19, and previous symptoms of COVID-19 did not significantly (p = 0.05) influence respondents' willingness to be vaccinated. 33 Based on the findings of this study, there is a need to strengthen the importance of information, communication, and organizational and educational strategies to reduce vaccine hesitancy.…”

Section: Gender Barriers Frequency Percentcontrasting

confidence: 61%

Acceptability rate and barriers to COVID-19 vaccination among healthcare workers in Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku-Awka, Nigeria

Joe-Ikechebelu,

Umeh,

Eleje

et al. 2023

Therapeutic Advances in Infection

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Background: Healthcare workers were at the forefront of the COVID-19 pandemic. The acceptability and uptake of COVID-19 vaccines among healthcare workers was an important strategy in halting the spread of the virus as well as the antecedent implications on global health and the world economy. Objectives: This study aims to determine the acceptability rate and barriers to COVID-19 vaccination of frontline healthcare workers in Awka, Nigeria. Design: This is an analytical cross-sectional study. Methods: An online cross-sectional survey was conducted from February 2022 to April 2022 to obtain the data for this study. One hundred healthcare workers were studied. Acceptability rate and barriers to uptake of COVID-19 vaccination were outcome measures. Results: The COVID-19 vaccination rate was 45.0% among healthcare workers in study area of Awka metropolis. Ages 30–39 years had the highest acceptance rate of COVID-19 vaccination, 19 (47.5%; p = 0.262) with a more female preponderance of COVID-19 vaccine acceptance compared to males [26 (41.3%) vs 16 (42.2%), p = 0.721]. The place of residence of respondents (urban vs rural) and their marital status (married vs single) appeared not to influence the acceptance of COVID-19 vaccination [(38 (42.2%) vs 3 (33.3%); p = 0.667; 25 (36.8% vs 17 (54.8%); p = 0.433)]. Years of work experience (<10 years vs >10 years) significantly affected COVID-19 vaccine acceptance [27 (45.8%) vs 12 (52.2%); p = 0.029]. Educational status and monthly income appeared not to influence vaccine uptake ( p > 0.05, for both). A significant number of respondents were not sure why they should or should not take the COVID-19 vaccine [49 (92.5%) vs 35 (83.3%); p = 0.001]. Conclusion: The COVID-19 vaccination rate is still poor among healthcare workers in Awka metropolis. The majority of respondents do not know why they should or should not take COVID-19 vaccine. We therefore recommend robust awareness campaigns that will explain in clear terms the essence and efficacy of COVID-19 vaccination in order to improve vaccine acceptance.

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Section: Gender Barriers Frequency Percentcontrasting

confidence: 61%

Acceptability rate and barriers to COVID-19 vaccination among healthcare workers in Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku-Awka, Nigeria

Joe-Ikechebelu,

Umeh,

Eleje

et al. 2023

Therapeutic Advances in Infection

View full text Add to dashboard Cite

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“… 4 This virus rapidly spread throughout the world and was declared a pandemic in March 2020 by the WHO. 3 , 5 – 7 On 27 February 2020, Nigeria recorded its first case of COVID-19 in an Italian national who flew to Nigeria through Milan, Italy, and the disease has spread to all the states of Nigeria causing many deaths. 7 It has also put pressure on the scarce health care resources in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Cesarean section rate and outcomes during and before the first wave of COVID-19 pandemic

et al. 2022

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Objectives: The objective of the study was to assess how the current COVID-19 pandemic has affected cesarean section (C-section) rates, indications, and peripartum outcomes. Methods: This was a retrospective cross-sectional study that compared a 3-month rates of and indications for C-sections at three tertiary health care institutions in Nigeria before (October 2019–December 2019) and during the first wave of COVID-19 pandemic (March 2020–May 2020). Primary outcomes were C-section rate and indications between the two periods. Data were analyzed using SPSS 26.0 IBM Corporation. Rates and odds ratios with 95% confidence intervals were used to quantify indications and peripartum outcomes and statistical significance was accepted when p value was <0.05. Results: The baseline characteristics of the two groups were similar. The C-section rate during the COVID-19 period was significantly less than the period prior to the pandemic (237/580, 40.0% vs 390/833, 46.8%; p = 0.027). The rates of postdatism (odds ratio = 1.47, 95% confidence interval = 1.05–2.05, p = 0.022), fetal distress (odds ratio = 3.06, 95% confidence interval = 1.55–6.06, p = 0.017), emergency C-section (odds ratio = 1.43, 95% confidence interval = 1.01–2.05, p = 0.042), and anemia (odds ratio = 1.84, 95% confidence interval = 1.12–3.03, p = 0.016) were significantly higher during the pandemic than prepandemic. Conclusion: The overall C-section rate during the first wave of COVID-19 was significantly lower than the prepandemic period. There were higher rates of postdatism, fetal distress, emergency C-section, and postpartum anemia. Further studies on this changing C-section trend during the pandemic are needed.

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“…Sneezing, talking and coughing produce respiratory droplets, which are media COVID-19 viruses that can spread between different people in close physical contact. When people fail to wash or sanitize their hands after touching contaminated surfaces, there is a high possibility of spreading as they eventually touch their eyes, faces and nose with those hands [ 1 , 2 ]. After the first case of COVID-19 was diagnosed in Nigeria on the 27th of February 2020, there have been several lock-downs and policies to curb the spread.…”

Section: Introductionmentioning

confidence: 99%

The impact of COVID-19 on the birth rate in Nigeria: A report from population-based registries

Oguejiofor¹,

Ebubechukwu²,

Eleje³

et al. 2023

Infect Dis Res

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Background and objectives: Coronavirus disease 2019 (COVID-19) is a pandemic that has become a major source of morbidity and mortality worldwide, affecting the physical and mental health of individuals influencing reproduction. Despite the threat, it poses to maternal health in sub-Saharan Africa and Nigeria, there is little or no data on the impact it has on fertility, conception, gestation and birth. To compare the birth rate between pre-COVID and COVID times using selected months of the year. Materials and methods: This was a secondary analysis of cross-sectional analytical study data from the birth registries of three tertiary hospitals, comparing two years [2019 (Pre-COVID)] versus [2020 (COVID era)] using three months of the year (October to December). The data relied upon was obtained from birth registries in three busy maternity clinics all within tertiary hospitals in South-East Nigeria and we aimed at discussing the potential impacts of COVID-19 on fertility in Nigeria. The secondary outcome measures were; mode of delivery, booking status of the participants, maternal age and occupation. Results: There was a significant decrease in tertiary-hospital based birth rate by 92 births ( P = 0.0009; 95% CI: −16.0519 to −4.1481) among mothers in all the three hospitals in 2020 during the COVID period (post lockdown months) of October to December. There was a significant difference in the mode of delivery for mothers ( P = 0.0096) with a 95% confidence interval of 1.0664 to 1.5916, as more gave birth through vaginal delivery during the 2020 COVID-19 period than pre-COVID-19. Conclusion: Tertiary-hospital based birth rates were reduced during the pandemic. Our multi-centre study extrapolated on possible factors that may have played a role in this decline in their birth rate, which includes but is not limited to; decreased access to hospital care due to the total lockdowns/curfews and worsening inflation and economic recession in the country.

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SARS-CoV-2: Current Perspective on Control, Prevention, and Therapeutic Promise

Cited by 4 publications

References 14 publications

Acceptability rate and barriers to COVID-19 vaccination among healthcare workers in Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku-Awka, Nigeria

Acceptability rate and barriers to COVID-19 vaccination among healthcare workers in Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku-Awka, Nigeria

Cesarean section rate and outcomes during and before the first wave of COVID-19 pandemic

The impact of COVID-19 on the birth rate in Nigeria: A report from population-based registries

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