SARS-CoV-2 (COVID-19) pneumonia: Incidental finding on 18F-FDG PET/CT study for vasculitis diagnosis

Dávila, Carmen Salvat; Fernández, Juan Pablo; Grande, M.L. Domínguez; Díaz, Carmen Vigil; Llana, B. Fernández; Fernández, Noelia Martín; García, Francisco Javier González

doi:10.1016/j.remnie.2020.08.004

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…We nevertheless confirm the findings of Sollini et al and of four other case reports showing signs of thoracic aortitis after SARS-Cov2 infection, all presenting with chest pain, reinforcing the hypothesis of a SARS-COV 2 post infectious aortic inflammation [ [3] , [4] , [5] , [6] ]. Supported by the SARS-CoV-2 pathophysiological mechanism of entry, which uses the ACE2 receptor present on endothelial cells, evidence of SARS-CoV2 virions inside vascular tissues has now emerging [ 7 ].…”

supporting

confidence: 91%

Aortic 18F-FDG PET/CT hypermetabolism in patients with long COVID: a retrospective study

Dudouet

Cammilleri

Guedj

et al. 2021

Clinical Microbiology and Infection

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supporting

confidence: 91%

Aortic 18F-FDG PET/CT hypermetabolism in patients with long COVID: a retrospective study

Dudouet

Cammilleri

Guedj

et al. 2021

Clinical Microbiology and Infection

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“…Inflammation of aorta has been described but attributed to infection with SARS-CoV-2 rather than vasculitis [ 94 ]. A reported case of large vessel vasculitis diagnosed on PET CT with associated Covid pneumonia presents the same dilemma [ 116 ]. Another case has been reported as LVV but with spontaneous resolution suggesting an infectious aortitis [ 117 ].…”

Section: Resultsmentioning

confidence: 99%

Rheumatological complications of Covid 19

Zacharias

Dubey

Koduri

et al. 2021

Autoimmunity Reviews

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Introduction COVID-19 has caused unprecedented hardships in the 21st century with more than 150 million infections. Various immunological phenomena have been described during the course of the infection, and this infection has also triggered autoimmunity. Rheumatological illnesses have been described following resolution of the acute infection; hence we sought to conduct a review of the rheumatological complications of COVID-19. Methods We conducted a literature search for articles relating to sequelae of COVID-19 from Jan 2020 to 30th April 2021. Results We found a number of reports of inflammatory arthritis after SARS-CoV-2 infection. SLE and renal disease have been described, and vasculitis also appears to be a common complication. Rhabdomyolysis and myositis has also been reported in a number of patients. We also found some evidence of large vessel vasculitis in ‘long COVID’ patients. Conclusions This review highlights a number of important complications such as inflammatory arthritis, lupus-like disease, myostis and vasculitis following SARS-CoV-2 infection.

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“…While autopsybased investigations illustrated the primary occurrences of vasculitis in the lungs and brain, 79,80 clinical reports unveil noteworthy cases of vasculitis in distinct regions, encompassing aortitis, splenic hilum artery vasculitis, as well as abdominal and bilateral common iliac arteritis. [11][12][13] Evidence of viral presence within endothelial cells supports the direct invasion hypothesis. 81 Furthermore, clinical observations elucidate the role of autoantibodies in COVID-19-induced vasculitis.…”

Section: Heart and Vascular Systemmentioning

confidence: 63%

“…SARS‐CoV‐2 exerts its influence on the cardiovascular system primarily by provoking systemic vasculitis through a combination of direct viral infection and autoimmune‐mediated mechanisms. While autopsy‐based investigations illustrated the primary occurrences of vasculitis in the lungs and brain, 79,80 clinical reports unveil noteworthy cases of vasculitis in distinct regions, encompassing aortitis, splenic hilum artery vasculitis, as well as abdominal and bilateral common iliac arteritis 11–13 . Evidence of viral presence within endothelial cells supports the direct invasion hypothesis 81 .…”

Section: Systemic Involvementmentioning

confidence: 96%

“…Beyond respiratory infiltration, SARS-CoV-2 poses significant threats to the Central Nervous System (CNS), as evidenced by the onset of diverse neurological complications such as aseptic meningitis, encephalopathy, myelopathy, Guillain-Barré Syndrome and anosmia or ageusia. 6,7 Equally compelling are reports highlighting vascular manifestations, notably thrombosis [8][9][10] and systemic vasculitis, [11][12][13] accompanied by haematological perturbations like heparin-induced thrombocytopenia (HIT), 10 autoimmune haemolytic anaemia (AIHA), 14,15 and immune thrombocytopenic purpura (ITP). [16][17][18] Furthermore, even organs such as the liver, thyroid, pancreas and reproductive systems are also targets for SARS-CoV-2, [19][20][21][22][23][24][25] attesting to the extensive systemic impact of the virus.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Unveiling the intricacies of COVID‐19: Autoimmunity, multi‐organ manifestations and the role of autoantibodies

Ding,

Wei,

Pan

et al. 2023

Scand J Immunol

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COVID‐19 is a severe infectious disease caused by a SARS‐CoV‐2 infection. It has caused a global pandemic and can lead to acute respiratory distress syndrome (ARDS). Beyond the respiratory system, the disease manifests in multiple organs, producing a spectrum of clinical symptoms. A pivotal factor in the disease's progression is autoimmunity, which intensifies its severity and contributes to multi‐organ injuries. The intricate interaction between the virus' spike protein and human proteins may engender the generation of autoreactive antibodies through molecular mimicry. This can further convolute the immune response, with the potential to escalate into overt autoimmunity. There is also emerging evidence to suggest that COVID‐19 vaccinations might elicit analogous autoimmune responses. Advanced technologies have pinpointed self‐reactive antibodies that target diverse organs or immune‐modulatory proteins. The interplay between autoantibody levels and multi‐organ manifestations underscores the importance of regular monitoring of serum antibodies and proinflammatory markers. A combination of immunosuppressive treatments and antiviral therapy is crucial for managing COVID‐19‐associated autoimmune diseases. The review will focus on the generation of autoantibodies in the context of COVID‐19 and their impact on organ health.

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SARS-CoV-2 (COVID-19) pneumonia: Incidental finding on 18F-FDG PET/CT study for vasculitis diagnosis

Cited by 5 publications

References 3 publications

Aortic 18F-FDG PET/CT hypermetabolism in patients with long COVID: a retrospective study

Aortic 18F-FDG PET/CT hypermetabolism in patients with long COVID: a retrospective study

Rheumatological complications of Covid 19

Unveiling the intricacies of COVID‐19: Autoimmunity, multi‐organ manifestations and the role of autoantibodies

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