SARS-CoV-2 Breakthrough Infection after mRNA-1273 Booster among CoronaVac-Vaccinated Healthcare Workers

Abstract

It remains unknown whether the Indonesian healthcare workers (HCWs) who had received two doses of CoronaVac vaccine and one dose of mRNA-1273 booster could be protected during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron wave. In total, 125 infection-naïve and 10 previously infected HCWs were recruited. The mRNA-1273 booster substantially increased titer of anti-SARS-CoV-2 spike protein receptor-binding domain antibodies. However, the monitoring revealed that 34 out of 125 infection-naïve (27.2%) and 3 out of 10 previously infected HCWs (30.0%) were infected during the Omicron wave. All infected HCWs were either asymptomatic or having mild coronavirus disease 2019 (COVID-19) and subsequently fully recovered, supporting the heterologous prime-boost strategy against COVID-19.

ANALISIS FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP PEMBENTUKAN IgG ANTI-SARS-CoV-2 PASCAVAKSINASI CoronaVac PADA MASYARAKAT KOTA CIMAHI

“…11 Di Indonesia sendiri baru ada penelitian yang mengevaluasi pengaruh usia, jenis kelamin dan riwayat infeksi terhadap respons imun pascavaksinasi CoronaVac. 12,13 Faktor yang berpengaruh pada respons imun pascavaksinasi di tiap wilayah bisa berbeda.…”

Hospitalized COVID‐19 patients with diabetes have an increased risk for pneumonia, intensive care unit requirement, intubation, and death: A cross‐sectional cohort study in Mexico in 2020

“…[4][5][6] Most COVID-19 infected individuals recover without the need for specialized medical care, and many do not exhibit any symptoms. 7,8 The severity of the disease is modulated by coexisting medical disorders. 9,10 Pneumonia or respiratory failure are common complications in COVID-19 cases and can be deadly.…”

“…Most COVID‐19 infected individuals recover without the need for specialized medical care, and many do not exhibit any symptoms. 7 , 8 The severity of the disease is modulated by coexisting medical disorders. 9 , 10 Pneumonia or respiratory failure are common complications in COVID‐19 cases and can be deadly.…”

Seroprevalence of SARS-CoV-2 anti-spike IgG antibody among COVID-19 vaccinated individuals residing in Surabaya, East Java, Indonesia

“…In Indonesia, several studies have highlighted the impact of COVID-19 vaccination on the elicitation of antibody responses. However, most studies are performed on healthcare workers receiving CoronaVac ( Santi et al, 2021 ; Cucunawangsih et al, 2021 , 2022 ; Hidayat et al, 2022 ). The seroprevalence of SARS-CoV-2-related antibodies among the general population, especially anti-S-IgG antibodies is rarely informed in Indonesia, while it plays an important role in neutralizing capability ( Kyriakidis et al, 2021 ; Tan et al, 2022 ).…”